Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing architecture-driven splicing bias in neuronal wiring

Hong, WL; Zhang, J; Dong, HY; Shi, Y; Ma, HR; Zhou, FY; Xu, BB; Fu, Y; Zhang, SX; Hou, SQ; Li, G; Wu, YD; Chen, S; Zhu, XH; You, WD; Shi, F; Yang, XF; Gong, ZF; Huang, JH; Jin, YF

Jin, YF (corresponding author), Zhejiang Univ, Coll Life Sci, MOE Lab Biosyst Homeostasis & Protect, ZJ-310058 Hangzhou, Zhejiang, Peoples R China.; Jin, YF (corresponding author), Zhejiang Univ, Coll Life Sci, Innovat Ctr Cell Signaling Network, ZJ-310058 Hangzhou, Zhejiang, Peoples R China.; Jin, YF (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Neurosurg, ZJ-310058 Hangzhou, Zhejiang, Peoples R China.

CELL REPORTS, 2021; 36 (2):

Abstract

Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) can generate 38,016 different isoforms through largely stochastic, yet highly bi......

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