Orthosteric and allosteric action of the C5a receptor antagonists

Liu, H; Kim, HR; Deepak, RNVK; Wang, L; Chung, KY; Fan, H; Wei, ZY; Zhang, C

Zhang, C (reprint author), Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15260 USA.

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018; 25 (6): 472

Abstract

The C5a receptor (C5aR) is a G-protein-coupled receptor (GPCR) that can induce strong inflammatory response to the anaphylatoxin C5a. Targeting C5aR h......

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