USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1 alpha/USP22 positive feedback loop upon TP53 inactivation

Ling, SB; Shan, QN; Zhan, QF; Ye, QW; Liu, P; Xu, SJ; He, X; Ma, J; Xiang, JJ; Jiang, GJ; Wen, X; Feng, ZJ; Wu, Y; Feng, TT; Xu, L; Chen, KC; Zhang, XY; Wei, RL; Zhang, CZ; Cen, BN; Xie, HY; Song, PH; Liu, JM; Zheng, SS; Xu, X

Xu, X (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310003, Zhejiang, Peoples R China.

GUT, 2020; 69 (7): 1322

Abstract

Objective We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific protease 22 (USP22) and hypoxia inducible factor-1 alpha (HIF1 a......

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