Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct

Huang, HH; Jin, WLW; Huang, M; Ji, HY; Capen, DE; Xia, Y; Yuan, JY; Paunescu, TG; Lu, HAJ

Lu, HAJ (corresponding author), Massachusetts Gen Hosp, Program Membrane Biol, Ctr Syst Biol, 185 Cambridge St,CPZN 8150, Boston, MA 02114 USA.; Lu, HAJ (corresponding author), Massachusetts Gen Hosp, Dept Med, Div Nephrol, 185 Cambridge St,CPZN 8150, Boston, MA 02114 USA.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (9): 2097

Abstract

Background Gentamicin is a potent aminoglycoside antibiotic that targets gram-negative bacteria, but nephrotoxicity limits its clinical application. T......

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