The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

Miao, NJ; Yin, F; Xie, HY; Wang, YZ; Xu, YA; Shen, Y; Xu, D; Yin, JY; Wang, B; Zhou, ZL; Cheng, Q; Chen, PP; Xue, H; Zhou, L; Liu, J; Wang, XX; Zhang, W; Lu, LM

Zhang, W; Lu, LM (reprint author), 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China.; Wang, XX (reprint author), 1111 Xianxia Rd, Shanghai 200336, Peoples R China.

KIDNEY INTERNATIONAL, 2019; 96 (5): 1105

Abstract

Inflammation and tubular cell death are the hallmarks of acute kidney injury. However, the precise mechanism underlying these effects has not been ful......

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