Deletion of IL-6 Exacerbates Colitis and Induces Systemic Inflammation in IL-10-Deficient Mice

Ye, M; Joosse, ME; Liu, L; Sun, Y; Dong, Y; Cai, CC; Song, ZM; Zhang, J; Brant, SR; Lazarev, M; Li, XH

Li, XH (corresponding author), Johns Hopkins Univ, Dept Med, Div Gastroenterol, Sch Med, 720 Rutland Ave,Ross 918, Baltimore, MD 21205 USA.

JOURNAL OF CROHNS & COLITIS, 2020; 14 (6): 831

Abstract

Background and Aims: Interleukin 6 [IL-6] or its receptor is currently a candidate for targeted biological therapy of inflammatory bowel disease [IBD]......

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