CXCL6-EGFR-induced Kupffer cells secrete TGF-beta 1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis

Cai, XB; Li, ZH; Zhang, QD; Qu, Y; Xu, MY; Wan, XJ; Lu, LG

Lu, LG (reprint author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Gastroenterol, Shanghai, Peoples R China.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018; 22 (10): 5050

Abstract

Liver fibrosis is the excessive accumulation of extracellular matrix proteins in response to the inflammatory response that accompanies tissue injury,......

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