Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution

Xu, Z; Takizawa, F; Casadei, E; Shibasaki, Y; Ding, Y; Sauters, TJC; Yu, YY; Salinas, I; Sunyer, JO

Sunyer, JO (corresponding author), Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA.; Salinas, I (corresponding author), Univ New Mexico, CETI, Dept Biol, Albuquerque, NM 87131 USA.

SCIENCE IMMUNOLOGY, 2020; 5 (44):

Abstract

Although mammalian secretory immunoglobulin A (sIgA) targets mucosal pathogens for elimination, its interaction with the microbiota also enables comme......

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