Discovery of a sigma(1) receptor antagonist by combination of unbiased cell painting and thermal proteome profiling

Wilke, J; Kawamura, T; Xu, H; Brause, A; Friese, A; Metz, M; Schepmann, D; Wunsch, B; Artacho-Cordon, A; Nieto, FR; Watanabe, N; Osada, H; Ziegler, S; Waldmann, H

Waldmann, H (corresponding author), Max Planck Inst Mol Physiol, Otto Hahn Str 11, D-44227 Dortmund, Germany.; Waldmann, H (corresponding author), TU Dortmund Univ, Emil Figge Str 72, D-44221 Dortmund, Germany.

CELL CHEMICAL BIOLOGY, 2021; 28 (6): 848

Abstract

Phenotypic screening for bioactive small molecules is typically combined with affinity-based chemical proteomics to uncover the respective molecular t......

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