PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

Navarro, J; Gozalbo-Lopez, B; Mendez, AC; Dantzer, F; Schreiber, V; Martinez, C; Arana, DM; Farres, J; Revilla-Nuin, B; Bueno, MF; Ampurdanes, C; Galindo-Campos, MA; Knobel, PA; Segura-Bayona, S; Martin-Caballero, J; Stracker, TH; Aparicio, P; Del Va

Yelamos, J (reprint author), Hosp del Mar, Med Res Inst IMIM, Canc Res Program, Barcelona, Spain.; Del Val, M (reprint author), UAM, CSIC, Ctr Biol Mol Severo Ochoa, Inmunol Viral, Madrid, Spain.; Yelamos, J (reprint author), Ctr Invest Biomed Red Enferme

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1)......

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