Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a beta-arrestin-1 dependent manner

Li, DJ; Tong, J; Li, YH; Meng, HB; Ji, QX; Zhang, GY; Zhu, JH; Zhang, WJ; Zeng, FY; Huang, G; Hua, X; Shen, FM; Wang, P

Shen, FM (reprint author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Pharm, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.; Wang, P (reprint author), Tongji Univ, Sch Med, 325 Guohe Rd, Shanghai 200433, Peoples R China.

JOURNAL OF PINEAL RESEARCH, 2019; 67 (4):

Abstract

Melatonin has been previously shown to prevent nonalcoholic fatty liver disease (NAFLD), yet the underlying mechanisms are poorly understood. Here, we......

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