LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1 alpha-FOXO4-p21-dependent signaling axis

Sun, XD; Thorne, RF; Zhang, XD; He, M; Li, JM; Feng, SS; Liu, XY; Wu, MA

Wu, MA (corresponding author), Univ Sci & Technol China, CAS Key Lab Innate Immun & Chron Dis, CAS Ctr Excellence Mol Cell Sci, Sch Life Sci, Hefei, Peoples R China.; Wu, MA (corresponding author), Univ Sci & Technol China, Affiliated Hosp 1, Hefei, Peoples R China.; Liu, XY; Wu, MA (corresponding author), Zhengzhou Univ, Translat Res Inst, Henan Prov Peoples Hosp, Acad Med Sci, Zhengzhou, Peoples R China.; Feng, SS (corresponding author), Jinan Univ, Key Lab Regenerat Med, Minist Educ, Dept Dev & Regenerat Biol, Guangzhou, Peoples R China.; Liu, XY (corresponding author), Anhui Med Univ, Sch Life Sci, Hefei, Peoples R China.; Wu, MA (corresponding author), Henan Univ, Key Lab Stem Cell Differentiat & Modificat, Sch Clin Med, Zhengzhou, Peoples R China.

EMBO REPORTS, 2020; 21 (4):

Abstract

The long noncoding RNA GUARDIN functions to protect genome stability. Inhibiting GUARDIN expression can alter cell fate decisions toward senescence or......

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