Baseline Plasma Zinc and Risk of First Stroke in Hypertensive Patients A Nested Case-Control Study

Zhang, JP; Cao, JJ; Zhang, YY; Li, H; Zhang, H; Huo, Y; Li, J; Liu, XY; Wang, XB; Qin, XH; Xu, XP

Xu, XP (reprint author), China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China.; Qin, XH (reprint author), Anhui Med Univ, Inst Biomed, Hefei 230032, Anhui, Peoples R China.; Qin, XH (re

STROKE, 2019; 50 (11): 3255


Background and Purpose- We aimed to examine the relation of baseline plasma zinc with the risk of first stroke and investigate any possible effect modifiers in hypertensive patients. Methods- The study population was drawn from the CSPPT (China Stroke Primary Prevention Trial), using a nested case-control design, including 599 first stroke cases and 599 matched controls. Results- Compared with participants with baseline plasma zinc <106.9 mu g/dL (median), a significantly lower risk of first hemorrhagic stroke was found in those with plasma zinc >= 106.9 mu g/dL (multivariate-adjusted odds ratio, 0.45; 95% CI, 0.21-0.94). Furthermore, the inverse plasma zinc-first hemorrhagic stroke association was significantly stronger in participants with body mass index >= 25.0 kg/m(2) or plasma copper <100.1 mu g/dL at baseline (P-interaction <0.05 for both variables). However, there was no significant association between plasma zinc and first ischemic stroke (<103.3 versus >= 103.3 mu g/dL [median]; multivariate-adjusted odds ratio, 1.16; 95% CI, 0.83-1.61). Conclusions- In this sample of hypertensive patients, we found a significant, inverse association between plasma zinc and first hemorrhagic stroke.

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