Quantitative proteomics reveals mitochondrial respiratory chain as a dominant target for carbon ion radiation: Delayed reactive oxygen species generation caused DNA damage

Fan, PC; Zhang, Y; Wang, Y; Wei, W; Zhou, YX; Xie, Y; Wang, X; Qi, YZ; Chang, L; Jia, ZP; Zhou, Z; Guan, H; Zhang, H; Xu, P; Zhou, PK

Xu, P (reprint author), Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing 102206, Peoples R China.; Zhou, PK (reprint author), Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing Key Lab R

FREE RADICAL BIOLOGY AND MEDICINE, 2019; 130 (): 436

Abstract

Heavy ion radiotherapy has shown great promise for cancer therapy. Understanding the cellular response mechanism to heavy ion radiation is required to......

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