An aged immune system drives senescence and ageing of solid organs

Yousefzadeh, MJ; Flores, RR; Zhu, Y; Schmiechen, ZC; Brooks, RW; Trussoni, CE; Cui, YX; Angelini, L; Lee, KA; McGowan, SJ; Burrack, AL; Wang, D; Dong, Q; Lu, AP; Sano, T; O'Kelly, RD; McGuckian, CA; Kato, JI; Bank, MP; Wade, EA; Pillai, SPS; Klug, J; Ladiges, WC; Burd, CE; Lewis, SE; LaRusso, NF; Vo, NV; Wang, YS; Kelley, EE; Huard, J; Stromnes, IM; Robbins, PD; Niedernhofer, LJ

Robbins, PD; Niedernhofer, LJ (corresponding author), Univ Minnesota, Inst Biol Aging & Metab, Minneapolis, MN 55455 USA.; Robbins, PD; Niedernhofer, LJ (corresponding author), Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.

NATURE, 2021; 594 (7861): 100

Abstract

Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly(1,2). To define the contribution of immune......

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