Antifibrotic cardioprotection of berberine via downregulating myocardial IGF-1 receptor-regulated MMP-2/MMP-9 expression in diabetic rats

Li, GH; Xing, WJ; Zhang, M; Geng, FH; Yang, HY; Zhang, HF; Zhang, X; Li, J; Dong, L; Gao, F

Gao, F (reprint author), Fourth Mil Med Univ, Sch Aerosp Med, 169 Changlexi Rd, Xian 710032, Shaanxi, Peoples R China.; Gao, F (reprint author), Fourth Mil Med Univ, Dept Cardiol, 169 Changlexi Rd, Xian 710032, Shaanxi, Peoples R China.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2018; 315 (4): H802

Abstract

Diabetic cardiac fibrosis increases ventricular stiffness and facilitates the occurrence of diastolic dysfunction. Our previous studies have shown tha......

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