HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1 alpha-dependent acyloxyacyl hydrolase expression

Liu, JL; Du, SY; Kong, QY; Zhang, XJ; Jiang, SR; Cao, XF; Li, YH; Li, CF; Chen, HQ; Ding, ZN; Liu, L

Liu, L (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Jiangsu Prov Key Lab Geriatr, Nanjing 210029, Peoples R China.; Liu, L (corresponding author), Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Me, Key Lab Targeted Intervent Cardiovasc Dis, Nanjing 210029, Peoples R China.

CELL DEATH AND DIFFERENTIATION, 2020; 27 (9): 2651

Abstract

Liver dysfunction is strongly associated with poor survival of sepsis patients. Cytosolic lipopolysaccharide (LPS) sensing by Caspase-4/5/11 for pyrop......

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