SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome

Yu, HB; Cheng, ST; Ren, F; Chen, Y; Shi, XF; Wong, VKW; Law, BYK; Ren, JH; Zhong, S; Chen, WX; Xu, HM; Zhang, ZZ; Hu, JL; Cai, XF; Hu, Y; Zhang, WL; Long, QX; He, L; Hu, ZW; Jiang, H; Zhou, HZ; Huang, AL; Chen, J

Huang, AL; Chen, J (corresponding author), Chongqing Med Univ, Key Lab Mol Biol Infect Dis Designated, Chinese Minist Educ, Chongqing, Peoples R China.

CLINICAL SCIENCE, 2021; 135 (12): 1505

Abstract

Chronic hepatitis B virus (HBV) infection is a significant public health burden worldwide. HBV covalently closed circular DNA (cccDNA) organized as a ......

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