RNA-dependent RNA targeting by CRISPR-Cas9

Strutt, SC; Torrez, RM; Kaya, E; Negrete, OA; Doudna, JA

Doudna, JA (reprint author), Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA.; Doudna, JA (reprint author), Howard Hughes Med Inst, Chevy Chase, MD 20815 USA.; Doudna, JA (reprint author), Univ Calif Berkeley, Dept Chem

ELIFE, 2018; 7 ():

Abstract

Double-stranded DNA (dsDNA) binding and cleavage by Cas9 is a hallmark of type II CRISPR-Cas bacterial adaptive immunity. All known Cas9 enzymes are t......

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