PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis

Bally, APR; Neeld, DK; Lu, PY; Majumder, P; Tang, Y; Barwick, BG; Wang, Q; Boss, JM

Boss, JM (corresponding author), Emory Univ, Sch Med, Dept Microbiol & Immunol, 1510 Clifton Rd,Room 3001, Atlanta, GA 30322 USA.; Boss, JM (corresponding author), Emory Univ, Sch Med, Emory Vaccine Ctr, 1510 Clifton Rd,Room 3001, Atlanta, GA 30322 USA.

JOURNAL OF IMMUNOLOGY, 2020; 204 (2): 449

Abstract

During prolonged exposure to Ags, such as chronic viral infections, sustained TCR signaling can result in T cell exhaustion mediated in part by expres......

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