eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/beta-catenin in gastric cancer

Zhai, ST; Lin, S; Lin, ZJ; Xu, JJ; Ji, T; Chen, K; Wu, K; Liu, H; Ying, HN; Fei, WQ; Wang, J; Fu, GX; Wang, YF; Hu, XT; Cai, XJ

Wang, YF; Cai, XJ (corresponding author), Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Gen Surg,Key Lab Laparoscop Tech Res Zhejian, Hangzhou 310016, Zhejiang, Peoples R China.; Hu, XT (corresponding author), Zhejiang Univ, Sir Run Run Shaw Hosp, Biomed Res Ctr, Hangzhou 310016, Zhejiang, Peoples R China.; Hu, XT (corresponding author), Zhejiang Univ, Sir Run Run Shaw Hosp, Key Lab Biotherapy Zhejiang Prov, Hangzhou 310016, Zhejiang, Peoples R China.

GASTRIC CANCER, 2020; 23 (3): 483

Abstract

Background Epigenetic aberrations of tumor suppressor genes (TSGs), particularly DNA methylation, are frequently involved in the pathogenesis of gastr......

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