Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure

Wu, PL; Yuan, X; Li, FQ; Zhang, JH; Zhu, W; Wei, M; Li, JB; Wang, XJ

Li, JB (reprint author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Cardiol, Shanghai, Peoples R China.; Wang, XJ (reprint author), Univ South Dakota, Div Basic Biomed Sci, Sanford Sch Med, Vermillion, SD 57069 USA.

CIRCULATION-HEART FAILURE, 2017; 10 (7):

Abstract

BACKGROUND: Lysosomal dysfunction is implicated in human heart failure for which ischemic heart disease is the leading cause. Altered myocardial expre......

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