Internal Ribosome Entry Site Dramatically Reduces Transgene Expression in Hematopoietic Cells in a Position-Dependent Manner

Zheng, QY; Zhang, XY; Yang, H; Xie, JY; Xie, YL; Chen, JZ; Yu, CH; Zhong, C

Yu, CH; Zhong, C (reprint author), Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200438, Peoples R China.; Yu, CH (reprint author), Univ Florida, Dept Pediat, Div Cellular & Mol Therapy, Coll Med, Gainesville, FL 32610 USA.; Yu, CH (reprint

VIRUSES-BASEL, 2019; 11 (10):

Abstract

Bicistronic transgene expression mediated by internal ribosome entry site (IRES) elements has been widely used. It co-expresses heterologous transgene......

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