Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells

Ryabaya, O; Prokofieva, A; Akasov, R; Khochenkov, D; Emelyanova, M; Burov, S; Markvicheva, E; Inshakov, A; Stepanova, E

Ryabaya, O (reprint author), NN Blokhin Natl Med Res Ctr Oncol, Dept Expt Diagnost & Tumor Therapy, 24 Kashirskoe Shosse, Moscow 115478, Russia.

BIOMEDICINE & PHARMACOTHERAPY, 2019; 109 (): 2548

Abstract

Melanoma is one of the most aggressive and treatment-resistant tumors that responsible for majority of skin-cancer related deaths. Here we propose a c......

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