Impacts of CYP2C19 genetic polymorphisms on bioavailability and effect on platelet adhesion of vicagrel, a novel thienopyridine P2Y(12)inhibitor

Zhang, YF; Zhu, XX; Zhan, Y; Li, XJ; Liu, C; Zhu, YT; Zhang, H; Wei, HJ; Xia, Y; Sun, HB; Liu, YQ; Lai, XJ; Gong, YC; Liu, XF; Li, YG; Ding, YH; Zhong, DF

Zhong, DF (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai, Peoples R China.; Zhu, XX (corresponding author), Jilin Univ, Hosp 1, Phase Clin Trial Unit 1, 71 Xinmin St, Changchun, Jilin, Peoples R China.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (9): 1860

Abstract

Aims We investigated the impacts of CYP2C19 polymorphisms on pharmacokinetics and pharmacodynamics of vicagrel in healthy Chinese subjects. Methods CY......

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