Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation

Xia, Q; Zhang, HW; Zhang, P; Li, Y; Xu, MC; Li, XB; Li, XJ; Dong, L

Dong, L (corresponding author), Beijing Inst Technol, Sch Life Sci, Beijing, Peoples R China.

ONCOGENE, 2020; 39 (36): 5902

Abstract

PI3K/Akt/mTOR signaling pathway activity is highly elevated in glioblastoma (GBM). Although rapamycin is known to inhibit this pathway, GBM patients a......

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