Long noncoding RNA GHET1 in human cancer

Li, JL; Jiang, XM; Li, ZL; Huang, LN; Zhou, YS; Liu, YP; Cui, YF

Cui, YF (reprint author), Harbin Med Univ, Dept Hepatopancreatobiliary Surg, Affiliated Hosp 2, 246 Xuefu Ave, Harbin 150086, Heilongjiang, Peoples R China.

CLINICA CHIMICA ACTA, 2019; 488 (): 111


LncRNAs are a group of noncoding RNAs that are > 200 nucleotides in length. These RNAs have no significant protein-coding potential due to the lack of obvious open reading frames. To date, accumulating evidence has demonstrated that dysregulation of lncRNAs exhibits indispensable roles in the pathological processes of human cancers. These RNAs function as either oncogenes or tumor suppressor genes to regulate proliferation, migration and invasion of cancer cells. GHET1, a prominent oncogenic lncRNA, is highly expressed in diverse malignancies. Furthermore, GHET1 performs key functions in carcinogenesis and progression, suggesting that GHET1 is expected to be a prospective biomarker or therapeutic target for cancers. In this review, we provide a summary of the current evidence concerning the biological functions, underlying mechanisms and clinical significance of GHET1 during tumor development.

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