胰腺癌-话题@MedSci

#胰腺癌#

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[GetTopicListResponse(id=2155767, encodeId=d2682155e67d7, content=<a href='/topic/show?id=7692105e040' target=_blank style='color:#2F92EE;'>#KRAS抑制剂#</a>与<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>组合治疗<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>临床试验开始, objectTitle=Cancer Cell：KRAS抑制剂与免疫疗法组合治疗胰腺癌临床试验开始, objectType=article, longId=789676, objectId=6454e8967636, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20221109/1668016299208_4754896.png, objectUrl=/article/show_article.do?id=6454e8967636, replyNumber=0, likeNumber=13, createdTime=2023-09-02, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=6454e8967636, moduleTitle=Cancer Cell：KRAS抑制剂与免疫疗法组合治疗胰腺癌临床试验开始, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=6454e8967636)], followStatus=false, userIsMember=true, type=1, lengthMark=0), GetTopicListResponse(id=2147210, encodeId=538c214e210c4, content=<a href='/topic/show?id=b711106410b6' target=_blank style='color:#2F92EE;'>#Nectin-4#</a>在人类的<a href='/topic/show?id=c3aa4e516d6' target=_blank style='color:#2F92EE;'>#尿路上皮癌#</a>、<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>、<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>、<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>、<a href='/topic/show?id=ccf410109188' target=_blank style='color:#2F92EE;'>#食管癌#</a>、<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>中高表达，但是它能否成为药物治疗<a href='/topic/show?id=07a69996557' target=_blank style='color:#2F92EE;'>#靶点#</a>还难说，因为它的涉及面太广，一旦成为药物，可能具有巨大的安全性难题！例如它在皮肤中广泛表达，会不会引发皮肤的很多不良反应？很多靶点最终能不能成药，还有很多难题有待突破。不过，看看目前正在进行的1-2期临床试验以后就能知晓一二了。, objectTitle=Nectin-4：全球下一个关注的靶点, objectType=article, longId=780623, objectId=a111e806237e, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20230707/9a1ca266c1b4414b9961f79470a22762.jpg, objectUrl=/article/show_article.do?id=a111e806237e, replyNumber=0, likeNumber=40, createdTime=2023-07-10, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=a111e806237e, moduleTitle=Nectin-4：全球下一个关注的靶点, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=a111e806237e)], followStatus=false, userIsMember=true, type=1, lengthMark=1), GetTopicListResponse(id=2144013, encodeId=acc82144013dd, content=<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>Cell 发表论文，首次证实乳腺癌组织中存在的多种独特“胞内菌”在肿瘤转移定植过程中发挥关键作用, objectTitle=胰腺癌, objectType=topic, longId=83976, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020910/1599727927303_4754896.jpg, objectUrl=null, replyNumber=0, likeNumber=14, createdTime=2023-06-21, rootId=0, userName=ms1907128386112981, userId=e0ad1894147, projectId=1, avatar=null, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2143266, encodeId=2d4a2143266d3, content=<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>努力 , objectTitle=胰腺癌, objectType=topic, longId=83976, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020910/1599727927303_4754896.jpg, objectUrl=null, replyNumber=0, likeNumber=17, createdTime=2023-06-17, rootId=0, userName=ms1907128386112981, userId=e0ad1894147, projectId=1, avatar=null, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2142724, encodeId=c8e52142e2471, content=<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>肿瘤细胞代谢有助于建立免疫抑制肿瘤微环境。CD73（ATP代谢中的关键酶）在细胞表面的异常表达导致腺苷的细胞外积累，其对肿瘤浸润淋巴细胞表现出直接的抑制作用。然而，关于CD73对肿瘤细胞内阴性免疫调节相关信号分子和转导途径的影响知之甚少。 2023年6月8日，浙江大学梁廷波及黄星共同通讯在Nature Communications 发表题为“Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner”的研究论文，该研究证明CD73在胰腺癌免疫抑制中的**功能，这是一种以肿瘤代谢、免疫微环境和免疫治疗耐药性之间复杂的串扰为特征的理想模型。在多种胰腺癌模型中观察到CD73特异性药物与免疫检查点阻断相结合的协同作用。, objectTitle=胰腺癌, objectType=topic, longId=83976, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020910/1599727927303_4754896.jpg, objectUrl=null, replyNumber=0, likeNumber=18, createdTime=2023-06-14, rootId=0, userName=yangchou, userId=88b489038, projectId=1, avatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2140936, encodeId=7c2d214093673, content=<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>学习, objectTitle=胰腺癌, objectType=topic, longId=83976, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020910/1599727927303_4754896.jpg, objectUrl=null, replyNumber=0, likeNumber=17, createdTime=2023-06-05, rootId=0, userName=ms1907128386112981, userId=e0ad1894147, projectId=1, avatar=null, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2140159, encodeId=ef8621401592d, content=<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>学习促进步, objectTitle=胰腺癌, objectType=topic, longId=83976, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020910/1599727927303_4754896.jpg, objectUrl=null, replyNumber=0, likeNumber=14, createdTime=2023-05-31, rootId=0, userName=ms1907128386112981, userId=e0ad1894147, projectId=1, avatar=null, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2131589, encodeId=27f421315890d, content=<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>her-2需要常规查一下, objectTitle=胰腺癌, objectType=topic, longId=83976, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020910/1599727927303_4754896.jpg, objectUrl=null, replyNumber=0, likeNumber=16, createdTime=2023-05-11, rootId=0, userName=ms1907128386112981, userId=e0ad1894147, projectId=1, avatar=null, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2131391, encodeId=578621313918d, content=<a href='/topic/show?id=f237106211b0' target=_blank style='color:#2F92EE;'>#仙鹤草素#</a>是<a href='/topic/show?id=f4782246ec' target=_blank style='color:#2F92EE;'>#Akt#</a>和<a href='/topic/show?id=735669505d' target=_blank style='color:#2F92EE;'>#ERK#</a>通路的双重抑制剂，可抑制<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>细胞增殖，如果真能抑制这两个通路，就是万能抗癌药物，事实上可能并不是。这样的研究价值很小，结论也可疑。仙鹤草素（3 mg/kg）,这个剂量没有实际价值。, objectTitle=Phytother Res：仙鹤草素是AKT和ERK通路的双重抑制剂，可抑制胰腺癌细胞增殖, objectType=article, longId=771399, objectId=60ace713993a, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230510/1683694092378_5610093.png, objectUrl=/article/show_article.do?id=60ace713993a, replyNumber=0, likeNumber=21, createdTime=2023-05-10, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=60ace713993a, moduleTitle=Phytother Res：仙鹤草素是AKT和ERK通路的双重抑制剂，可抑制胰腺癌细胞增殖, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=60ace713993a)], followStatus=false, userIsMember=true, type=1, lengthMark=0), GetTopicListResponse(id=2130452, encodeId=21c82130452d8, content=<a href='/topic/show?id=dc29e50954f' target=_blank style='color:#2F92EE;'>#秦叔逵#</a>、<a href='/topic/show?id=9b41614554a' target=_blank style='color:#2F92EE;'>#李进#</a>教授发现<a href='/topic/show?id=3fca4e359e3' target=_blank style='color:#2F92EE;'>#尼妥珠单抗#</a>联合<a href='/topic/show?id=10dc3890e66' target=_blank style='color:#2F92EE;'>#吉西他滨#</a>可提高<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>患者疗效, objectTitle=ASCO 2022：秦叔逵、李进教授发现尼妥珠单抗联合吉西他滨可提高胰腺癌患者疗效, objectType=article, longId=729412, objectId=4900e294125e, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20220608/60242e4ac3e24371bf3be83904cfc37c.jpg, objectUrl=/article/show_article.do?id=4900e294125e, replyNumber=0, likeNumber=24, createdTime=2023-05-06, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=4900e294125e, moduleTitle=ASCO 2022：秦叔逵、李进教授发现尼妥珠单抗联合吉西他滨可提高胰腺癌患者疗效, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=4900e294125e)], followStatus=false, userIsMember=true, type=1, lengthMark=0), GetTopicListResponse(id=2130434, encodeId=f44c2130434db, content=二代#Claudin18.2#单抗<a href='/topic/show?id=12f41061484a' target=_blank style='color:#2F92EE;'>#Osemitamab#</a>（TST001，<a href='/topic/show?id=d5861061495e' target=_blank style='color:#2F92EE;'>#奥塞米单抗#</a>）获得<a href='/topic/show?id=f336e29134' target=_blank style='color:#2F92EE;'>#FDA#</a>颁发的孤儿药资格认定，用于治疗<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>，这是TST001继2021年获得FDA批准治疗<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a></a>及胃食管连接部癌孤儿药之后的第二项认定。<a href='/topic/show?id=b5f71041887c' target=_blank style='color:#2F92EE;'>#ADC类药物#</a> Claudin18.2可以表达在<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a></a>（70%），胰腺肿瘤（50%），<a href='/topic/show?id=ccf410109188' target=_blank style='color:#2F92EE;'>#食管癌#</a>（30%），<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>，<a href='/topic/show?id=3263e877271' target=_blank style='color:#2F92EE;'>#结肠癌#</a>，<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a>，<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>和肺腺癌上，因此，作为一个<a href='/topic/show?id=52d4106150f1' target=_blank style='color:#2F92EE;'>#泛癌种靶点#</a>, objectTitle=再下一城！比肩HER2，Claudin18.2成消化道肿瘤明星靶点！, objectType=article, longId=770058, objectId=15cde7005892, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/101r.jpg, objectUrl=/article/show_article.do?id=15cde7005892, replyNumber=1, likeNumber=51, createdTime=2023-05-06, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=15cde7005892, moduleTitle=再下一城！比肩HER2，Claudin18.2成消化道肿瘤明星靶点！, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=15cde7005892)], followStatus=false, userIsMember=true, type=1, lengthMark=1), GetTopicListResponse(id=2129625, encodeId=b36b212962583, content=以色列魏茨曼研究所的研究人员通过对<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>、<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>、<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>、<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>、<a href='/topic/show?id=330410333110' target=_blank style='color:#2F92EE;'>#黑色素瘤#</a>、<a href='/topic/show?id=68e5101e4167' target=_blank style='color:#2F92EE;'>#骨癌#</a>和<a href='/topic/show?id=6ba485016cd' target=_blank style='color:#2F92EE;'>#脑肿瘤#</a>这7种常见实体瘤的超过1526个样本的分析，发现大部分<a href='/topic/show?id=13db460162d' target=_blank style='color:#2F92EE;'>#实体瘤#</a>中含有细菌，这些细菌大多是存在于癌细胞内的“<a href='/topic/show?id=1f68104881ab' target=_blank style='color:#2F92EE;'>#胞内菌#</a>”。<a href='/topic/show?id=d14810605097' target=_blank style='color:#2F92EE;'>#肿瘤内细菌#</a><a href='/topic/show?id=1788106051d3' target=_blank style='color:#2F92EE;'>#瘤内细菌#</a>。这些胞内菌，或瘤内细菌参与了肿瘤的复杂生物学行为，包括促进肿瘤的转移，肿瘤的增殖，当然，也介导了<a href='/topic/show?id=8fe4828097b' target=_blank style='color:#2F92EE;'>#肿瘤免疫#</a>，因此，合理利用这些细菌，可能有助于<a href='/topic/show?id=a07f82814ec' target=_blank style='color:#2F92EE;'>#肿瘤免疫治疗#</a>。这些细菌是多样的，大多是<a href='/topic/show?id=805e36980c5' target=_blank style='color:#2F92EE;'>#厌氧菌#</a>和<a href='/topic/show?id=bde599869c0' target=_blank style='color:#2F92EE;'>#革兰氏阴性菌#</a>为主，如<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>，未来可以通过<a href='/topic/show?id=26b341e33ee' target=_blank style='color:#2F92EE;'>#基因工程#</a>进行减毒，然后应用于临床。, objectTitle=专访西湖大学蔡尚：肿瘤细胞内确实存在细菌，它们驱动了肿瘤转移, objectType=article, longId=724274, objectId=80d4e2427409, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20220414/1649911635167_5295905.jpg, objectUrl=/article/show_article.do?id=80d4e2427409, replyNumber=0, likeNumber=52, createdTime=2023-05-02, 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target=_blank style='color:#2F92EE;'>#结直肠癌#</a>、<a href='/topic/show?id=942b4516096' target=_blank style='color:#2F92EE;'>#子宫内膜癌#</a>和<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>。升高的 LDHA 和 LDHB 水平与<a href='/topic/show?id=d8dbe130197' target=_blank style='color:#2F92EE;'>#癌症#</a>患者的不良预后有关。因此，<a href='/topic/show?id=2f9c10e5635' target=_blank style='color:#2F92EE;'>#LDH#</a>（以下简称 LDHA 和 LDHB）已被公认为一种有前途的抗癌药物<a href='/topic/show?id=07a69996557' target=_blank style='color:#2F92EE;'>#靶点#</a>。选择 VHL hijack（劫持）E3连接酶，而不是 cereblon (CRBN)，主要是为了避免 CRBN 新底物降解引起的潜在并发症。可以这样说，<a href='/topic/show?id=0f6b2381e13' target=_blank style='color:#2F92EE;'>#乳酸脱氢酶#</a>，可能是实体瘤的通用靶点，乳酸脱氢酶 <a href='/topic/show?id=c6f814e5136' target=_blank style='color:#2F92EE;'>#PROTAC#</a> <a href='/topic/show?id=f259105e132a' target=_blank style='color:#2F92EE;'>#蛋白降解剂#</a>能够极大改善肿瘤内部的<a href='/topic/show?id=430750648d8' target=_blank style='color:#2F92EE;'>#微环境#</a>，尤其是<a 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style='color:#2F92EE;'>#卵巢早衰#</a>，因此，它用于<a href='/topic/show?id=3469e71246f' target=_blank style='color:#2F92EE;'>#红斑狼疮#</a>治疗一直是慎重的。<a href='/topic/show?id=9e5f10568e0b' target=_blank style='color:#2F92EE;'>#羟基雷公藤内酯醇#</a>（<a href='/topic/show?id=8fab105688b9' target=_blank style='color:#2F92EE;'>#雷腾舒#</a>）成功解决了这一问题。它来自雷公藤活性成分<a href='/topic/show?id=e8c51041521c' target=_blank style='color:#2F92EE;'>#雷公藤甲素#</a>。是不是可以理解为是<a href='/topic/show?id=797a1056897b' target=_blank style='color:#2F92EE;'>#羟基雷公藤甲素#</a>？C-14位羟化？雷公藤甲素是药用植物雷公藤（Tripterygium wilfordii Hook. f.）的主要活性成分之一，具有显著的抗炎、免疫抑制、抗肿瘤等生物活性，对<a href='/topic/show?id=7face61750b' target=_blank style='color:#2F92EE;'>#类风湿性关节炎#</a>、<a href='/topic/show?id=257ae692755' target=_blank style='color:#2F92EE;'>#系统性红斑狼疮#</a>等自身免疫系统疾病，<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>、肺癌等多种癌症具有较好的治疗作用。基于雷公藤甲素构效机制研发的多种衍生药物已进入临床试验阶段，其中大量的修饰改造工作是针对C-14位羟基进行的。雷公藤甲素又称雷公藤内酯、雷公藤内酯醇, 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style='color:#2F92EE;'>#Enhertu#</a>，<a href='/topic/show?id=2f1862e434' target=_blank style='color:#2F92EE;'>#DS-8201#</a>）II期临床数据在泛HER2表达晚期<a href='/topic/show?id=13db460162d' target=_blank style='color:#2F92EE;'>#实体瘤#</a>的持久反应，Enhertu（5.4mg/kg）治疗HER2表达肿瘤的疗效和安全性，包括<a href='/topic/show?id=a9ef83546d6' target=_blank style='color:#2F92EE;'>#胆道癌#</a>、<a href='/topic/show?id=843a85e9421' target=_blank style='color:#2F92EE;'>#膀胱癌#</a>、<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a>、<a href='/topic/show?id=942b4516096' target=_blank style='color:#2F92EE;'>#子宫内膜癌#</a>、<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>、<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>和罕见肿瘤。<a href='/topic/show?id=e0df9e832a7' target=_blank style='color:#2F92EE;'>#阿斯利康#</a>和<a href='/topic/show?id=446ae5737da' target=_blank style='color:#2F92EE;'>#第一三共#</a>会收获很多，<a href='/topic/show?id=f336e29134' 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type=1, lengthMark=1), GetTopicListResponse(id=2117677, encodeId=b3ba211e67707, content=<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>, objectTitle=美国国立综合癌症网络临床实践指南：胰腺癌(2022.V1)更新解读, objectType=guider, longId=22421, objectId=9da251c0029e8207, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/guideline/show_article.do?id=9da251c0029e8207, replyNumber=0, likeNumber=30, createdTime=2023-03-05, rootId=0, userName=lifestar, userId=aa0e14, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=9da251c0029e8207, moduleTitle=美国国立综合癌症网络临床实践指南：胰腺癌(2022.V1)更新解读, moduleType=guider, hrefUrl=https://www.medsci.cn/guideline/show_article.do?id=9da251c0029e8207)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

何时让癌王不再是癌王？！

2020-05-29

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#KRAS抑制剂#与#免疫疗法#组合治疗#胰腺癌#临床试验开始

Cancer Cell：KRAS抑制剂与免疫疗法组合治疗胰腺癌临床试验开始

2023-09-02发表于上海

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全文收起 #Nectin-4#在人类的#尿路上皮癌#、#肺癌#、#乳腺癌#、#卵巢癌#、#食管癌#、#胰腺癌#中高表达，但是它能否成为药物治疗#靶点#还难说，因为它的涉及面太广，一旦成为药物，可能具有巨大的安全性难题！例如它在皮肤中广泛表达，会不会引发皮肤的很多不良反应？很多靶点最终能不能成药，还有很多难题有待突破。不过，看看目前正在进行的1-2期临床试验以后就能知晓一二了。

Nectin-4：全球下一个关注的靶点

2023-07-10发表于上海

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#胰腺癌#Cell 发表论文，首次证实乳腺癌组织中存在的多种独特“胞内菌”在肿瘤转移定植过程中发挥关键作用

2023-06-21

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#胰腺癌#努力

2023-06-17

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全文收起 #胰腺癌#肿瘤细胞代谢有助于建立免疫抑制肿瘤微环境。CD73（ATP代谢中的关键酶）在细胞表面的异常表达导致腺苷的细胞外积累，其对肿瘤浸润淋巴细胞表现出直接的抑制作用。然而，关于CD73对肿瘤细胞内阴性免疫调节相关信号分子和转导途径的影响知之甚少。 2023年6月8日，浙江大学梁廷波及黄星共同通讯在Nature Communications 发表题为“Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner”的研究论文，该研究证明CD73在胰腺癌免疫抑制中的**功能，这是一种以肿瘤代谢、免疫微环境和免疫治疗耐药性之间复杂的串扰为特征的理想模型。在多种胰腺癌模型中观察到CD73特异性药物与免疫检查点阻断相结合的协同作用。

2023-06-14

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#胰腺癌#学习

2023-06-05

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#胰腺癌#学习促进步

2023-05-31

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#胰腺癌#her-2需要常规查一下

2023-05-11

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