DNA损伤修复-话题@MedSci

#DNA损伤修复#

10篇内容 | 604人围观

关注话题

话题活跃用户

#插入话题

插入图片

最新最热

[GetTopicListResponse(id=2160743, encodeId=40662160e4327, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a> 染色质松弛是DNA修复机制进入双链断裂(DSBs)的先决条件。然后，DSBs周围的局部组蛋白发生乙酰化状态的迅速变化，但如何满足乙酰辅酶A的大量需求尚不清楚。 2023年9月21日，深圳大学朱卫国团队在Nature Structural & Molecular Biology 在线发表题为“PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair”的研究论文，该研究报道了丙酮酸脱氢酶1α (PDHE1α)催化丙酮酸代谢，能够在DNA损伤反应中迅速提供乙酰辅酶A。, objectTitle=DNA损伤修复, objectType=topic, longId=6104, objectId=null, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=null, replyNumber=0, likeNumber=28, createdTime=2023-10-03, rootId=0, userName=yangchou, userId=88b489038, projectId=1, avatar=, status=1, hasArticle=0, attachment=null, ipAttribution=浙江省, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2034093, encodeId=26512034093f2, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=Eur J Cancer：DNA损伤修复状态对卡巴他赛治疗转移性去势抵抗性前列腺癌的活性的影响, objectType=article, longId=220037, objectId=996422003ee6, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=996422003ee6, replyNumber=0, likeNumber=54, createdTime=2022-09-23, rootId=0, userName=hb2008ye, userId=4c37265, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=996422003ee6, moduleTitle=Eur J Cancer：DNA损伤修复状态对卡巴他赛治疗转移性去势抵抗性前列腺癌的活性的影响, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=996422003ee6)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2034092, encodeId=0c162034092f9, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=Eur Urol：致病性生殖系DNA损伤修复变异对新辅助激素阻断疗法响应的影响, objectType=article, longId=211368, objectId=35b521136835, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=35b521136835, replyNumber=0, likeNumber=44, createdTime=2021-05-30, rootId=0, userName=zsyan, userId=dab8203, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=35b521136835, moduleTitle=Eur Urol：致病性生殖系DNA损伤修复变异对新辅助激素阻断疗法响应的影响, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=35b521136835)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2034091, encodeId=f24c203409162, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=PNAS: 郑晓峰揭示DNA损伤修复调控的新机制, objectType=article, longId=184224, objectId=522118422463, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=522118422463, replyNumber=0, likeNumber=41, createdTime=2020-03-27, rootId=0, userName=zsyan, userId=dab8203, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=522118422463, moduleTitle=PNAS: 郑晓峰揭示DNA损伤修复调控的新机制, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=522118422463)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2034090, encodeId=e8fe2034090ef, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=CLIN CANCER RES：DNA损伤修复基因突变与接受FOLFIRINOX治疗的胰腺导管癌患者预后改善有关, objectType=article, longId=156364, objectId=7f2a1563646d, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=7f2a1563646d, replyNumber=0, likeNumber=46, createdTime=2019-07-07, rootId=0, userName=zsyan, userId=dab8203, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=7f2a1563646d, moduleTitle=CLIN CANCER RES：DNA损伤修复基因突变与接受FOLFIRINOX治疗的胰腺导管癌患者预后改善有关, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=7f2a1563646d)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2034088, encodeId=9ce2203408809, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=Cell Discov：生态中心汪海林研究组在DNA损伤修复研究方面取得进展, objectType=article, longId=96772, objectId=668b96e72d9, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=668b96e72d9, replyNumber=0, likeNumber=45, createdTime=2017-09-05, rootId=0, userName=zsyan, userId=dab8203, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=668b96e72d9, moduleTitle=Cell Discov：生态中心汪海林研究组在DNA损伤修复研究方面取得进展, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=668b96e72d9)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2034087, encodeId=e5a6203408e6d, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=EMBO Reports：昆明动物所揭示DNA去甲基化与DNA损伤修复之间的调控作用, objectType=article, longId=93793, objectId=b65993e9379, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=b65993e9379, replyNumber=0, likeNumber=39, createdTime=2017-12-31, rootId=0, userName=zsyan, userId=dab8203, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=b65993e9379, moduleTitle=EMBO Reports：昆明动物所揭示DNA去甲基化与DNA损伤修复之间的调控作用, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=b65993e9379)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2034089, encodeId=c7ce20340898b, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=Nat Neurosci：痴呆症等神经退行性疾病新机制：DNA损伤修复遭破坏, objectType=article, longId=106616, objectId=457910661641, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=457910661641, replyNumber=0, likeNumber=50, createdTime=2017-10-26, rootId=0, userName=zsyan, userId=dab8203, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=457910661641, moduleTitle=Nat Neurosci：痴呆症等神经退行性疾病新机制：DNA损伤修复遭破坏, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=457910661641)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2034086, encodeId=b4b52034086ff, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=Immunity：DNA损伤修复酶调节炎症小体激活机制, objectType=article, longId=73348, objectId=67d0e334885, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=67d0e334885, replyNumber=0, likeNumber=45, createdTime=2017-04-06, rootId=0, userName=zsyan, userId=dab8203, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=67d0e334885, moduleTitle=Immunity：DNA损伤修复酶调节炎症小体激活机制, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=67d0e334885)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2034085, encodeId=c6112034085d5, content=<a href='/topic/show?id=157561045e' target=_blank style='color:#2F92EE;'>#DNA损伤修复#</a>, objectTitle=Mol Cell：特殊蛋白复合物在DNA损伤修复过程中的作用, objectType=article, longId=55812, objectId=14405581207, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=14405581207, replyNumber=0, likeNumber=46, createdTime=2016-01-12, rootId=0, userName=zsyan, userId=dab8203, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=14405581207, moduleTitle=Mol Cell：特殊蛋白复合物在DNA损伤修复过程中的作用, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=14405581207)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

2020-05-29

yangchou (审核中...)

前往app查看评论内容

全文收起 #DNA损伤修复# 染色质松弛是DNA修复机制进入双链断裂(DSBs)的先决条件。然后，DSBs周围的局部组蛋白发生乙酰化状态的迅速变化，但如何满足乙酰辅酶A的大量需求尚不清楚。 2023年9月21日，深圳大学朱卫国团队在Nature Structural & Molecular Biology 在线发表题为“PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair”的研究论文，该研究报道了丙酮酸脱氢酶1α (PDHE1α)催化丙酮酸代谢，能够在DNA损伤反应中迅速提供乙酰辅酶A。

2023-10-03发表于浙江省

hb2008ye (审核中...)

前往app查看评论内容

#DNA损伤修复#

Eur J Cancer：DNA损伤修复状态对卡巴他赛治疗转移性去势抵抗性前列腺癌的活性的影响

2022-09-23

zsyan (审核中...)

前往app查看评论内容

#DNA损伤修复#

Eur Urol：致病性生殖系DNA损伤修复变异对新辅助激素阻断疗法响应的影响

2021-05-30

zsyan (审核中...)

前往app查看评论内容

#DNA损伤修复#

PNAS: 郑晓峰揭示DNA损伤修复调控的新机制

2020-03-27

zsyan (审核中...)

前往app查看评论内容

#DNA损伤修复#

CLIN CANCER RES：DNA损伤修复基因突变与接受FOLFIRINOX治疗的胰腺导管癌患者预后改善有关

2019-07-07

zsyan (审核中...)

前往app查看评论内容

#DNA损伤修复#

Cell Discov：生态中心汪海林研究组在DNA损伤修复研究方面取得进展

2017-09-05

zsyan (审核中...)

前往app查看评论内容

#DNA损伤修复#

EMBO Reports：昆明动物所揭示DNA去甲基化与DNA损伤修复之间的调控作用

2017-12-31

zsyan (审核中...)

前往app查看评论内容

#DNA损伤修复#

Nat Neurosci：痴呆症等神经退行性疾病新机制：DNA损伤修复遭破坏

2017-10-26

zsyan (审核中...)

前往app查看评论内容

#DNA损伤修复#

Immunity：DNA损伤修复酶调节炎症小体激活机制

2017-04-06

zsyan (审核中...)

前往app查看评论内容

#DNA损伤修复#

Mol Cell：特殊蛋白复合物在DNA损伤修复过程中的作用

2016-01-12

科室
- - 订阅+
  - 更多科室
工具
服务