黄芪-话题@MedSci

#黄芪#

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[GetTopicListResponse(id=2242315, encodeId=1158224231591, content=<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>甲苷家族的化合物具备激活<a href='/topic/show?id=8d2d122315fb' target=_blank style='color:#2F92EE;'>#RXRa#</a>和改善线粒体功能的潜能。基于此，研究推测<a href='/topic/show?id=b9091031981b' target=_blank style='color:#2F92EE;'>#黄芪甲苷#</a>可能作为RXRa同型二聚体的潜在激活剂。<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a><a href='/topic/show?id=f5cb5192610' target=_blank style='color:#2F92EE;'>#心衰#</a> 黄芪作为补气的<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a>，对于心衰等很多慢性疾病有相当好的治疗效果，只是其中的有效成分并不明确。 , objectTitle=北京中医药大学揭秘黄芪甲苷III激活RXRa机制，心力衰竭治疗迎来曙光！, objectType=article, longId=855171, objectId=350d8551e120, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20241126/1732608584713_8538692.png, objectUrl=/article/show_article.do?id=350d8551e120, replyNumber=0, likeNumber=0, createdTime=2024-12-14, rootId=0, userName=侠胆医心, 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Ethnopharmacol：黄芪-当归药对通过AMPK/mTOR信号通路促进大鼠大脑中动脉闭塞/再灌注后的自噬活性减轻焦亡, objectType=article, longId=848982, objectId=fb1f848982e4, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20240726/1721975784253_8538692.png, objectUrl=/article/show_article.do?id=fb1f848982e4, replyNumber=0, likeNumber=49, createdTime=2024-10-29, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=fb1f848982e4, moduleTitle=J Ethnopharmacol：黄芪-当归药对通过AMPK/mTOR信号通路促进大鼠大脑中动脉闭塞/再灌注后的自噬活性减轻焦亡, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=fb1f848982e4)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2221492, encodeId=b2c02221492c4, content=<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a> <a href='/topic/show?id=d792114451e3' target=_blank style='color:#2F92EE;'>#脑缺血/再灌注损伤#</a>, objectTitle=黄芪-红花如何神奇逆转脑缺血/再灌注损伤：空间代谢组学的惊人发现！, objectType=article, longId=839740, objectId=7751839e4036, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2021923/1632391715336_5552845.webp, objectUrl=/article/show_article.do?id=7751839e4036, replyNumber=0, likeNumber=199, createdTime=2024-08-20, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=7751839e4036, moduleTitle=黄芪-红花如何神奇逆转脑缺血/再灌注损伤：空间代谢组学的惊人发现！, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=7751839e4036)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2172150, encodeId=64e821e2150ee, content=利用双样本<a href='/topic/show?id=73af45392ca' target=_blank style='color:#2F92EE;'>#孟德尔随机化#</a>（MR）研究<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>与<a href='/topic/show?id=cb65813029a' target=_blank style='color:#2F92EE;'>#肝硬化#</a>之间的潜在因果关系。 <a href='/topic/show?id=de675021419' target=_blank style='color:#2F92EE;'>#当归#</a>、<a href='/topic/show?id=5eb12311579' target=_blank style='color:#2F92EE;'>#丹参#</a>、<a href='/topic/show?id=497610533696' target=_blank style='color:#2F92EE;'>#茯苓#</a>、<a href='/topic/show?id=37fd105333e0' target=_blank style='color:#2F92EE;'>#白芍#</a>、<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>、<a href='/topic/show?id=ec1c1055e7c6' target=_blank style='color:#2F92EE;'>#苍术#</a>为主要药用植物。植物性药物和<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>靶向<a href='/topic/show?id=43eb1080e586' target=_blank style='color:#2F92EE;'>#MAPK1#</a>、VEGFA、<a href='/topic/show?id=684f16e52c8' target=_blank style='color:#2F92EE;'>#STAT3#</a>、AKT1、RELA、JUN和ESR1治疗<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>肝硬化，它们的联合使用显示出肝硬化治疗的希望。, objectTitle=Front Cell Infect 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href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>、<a href='/topic/show?id=864829232bd' target=_blank style='color:#2F92EE;'>#党参#</a>、<a href='/topic/show?id=b7c210666544' target=_blank style='color:#2F92EE;'>#积雪草#</a>、<a href='/topic/show?id=5eb12311579' target=_blank style='color:#2F92EE;'>#丹参#</a>、<a href='/topic/show?id=915a106666e1' target=_blank style='color:#2F92EE;'>#菟丝子#</a>、<a href='/topic/show?id=f385440e4d3' target=_blank style='color:#2F92EE;'>#大黄#</a>。临床研究表明，GBXZD可缓解患者疲劳、恶心等症状，改善肾功能；但其具体作用机制还有待进一步阐明。作用应该具有调节<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>，降肌酐的作用, objectTitle=J Ethnopharmacol：固本泻浊汤通过Raf1/p-Elk1信号轴抑制M1极化，减轻肾间质纤维化, objectType=article, longId=793102, objectId=5d8de93102d2, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230922/1695368159538_5610093.png, objectUrl=/article/show_article.do?id=5d8de93102d2, replyNumber=0, likeNumber=175, createdTime=2023-09-23, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=5d8de93102d2, moduleTitle=J Ethnopharmacol：固本泻浊汤通过Raf1/p-Elk1信号轴抑制M1极化，减轻肾间质纤维化, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=5d8de93102d2)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2159219, encodeId=81a821592195b, content=基于<a href='/topic/show?id=8d82e952353' target=_blank style='color:#2F92EE;'>#网络药理学#</a>的<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a><a href='/topic/show?id=c24a106655c4' target=_blank style='color:#2F92EE;'>#四君子汤#</a>治疗<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>机制研究, objectTitle=EBCAM:基于网络药理学的黄芪四君子汤治疗阿尔茨海默病机制研究, objectType=article, longId=219026, objectId=a3772190266c, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20211021/1634820905111_5570441.png, objectUrl=/article/show_article.do?id=a3772190266c, replyNumber=0, likeNumber=132, createdTime=2023-09-23, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=a3772190266c, moduleTitle=EBCAM:基于网络药理学的黄芪四君子汤治疗阿尔茨海默病机制研究, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=a3772190266c)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2130151, encodeId=198c21301514a, content=<a href='/topic/show?id=e12f5021543' target=_blank style='color:#2F92EE;'>#当归补血汤#</a>（<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>（AR）和<a href='/topic/show?id=de675021419' target=_blank style='color:#2F92EE;'>#当归#</a>（ASR））通过上调APP/PS1小鼠组蛋白H4赖氨酸12<a href='/topic/show?id=ddd623463b1' target=_blank style='color:#2F92EE;'>#乙酰化#</a>作用改善<a 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lengthMark=0), GetTopicListResponse(id=2126300, encodeId=450d212630046, content=<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>、<a href='/topic/show?id=435f105361f0' target=_blank style='color:#2F92EE;'>#莪术#</a>这一<a href='/topic/show?id=8f38105398c2' target=_blank style='color:#2F92EE;'>#药对#</a>研究十分火！很多<a href='/topic/show?id=57f74103502' target=_blank style='color:#2F92EE;'>#国自然#</a><a href='/topic/show?id=c030421865b' target=_blank style='color:#2F92EE;'>#基金#</a>均有这样的研究，而且主要集中于<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>领域。事实上，<a href='/topic/show?id=8a0410588826' target=_blank style='color:#2F92EE;'>#补气活血#</a>，确实是主要的治疗方法，这里说促进<a href='/topic/show?id=afc929130ad' target=_blank style='color:#2F92EE;'>#免疫细胞#</a>优势，从而促进血管正常化，有点混乱，但是如果研究二者结合，改善<a href='/topic/show?id=f0838291817' target=_blank style='color:#2F92EE;'>#肿瘤微环境#</a>，从而重塑<a href='/topic/show?id=6f9882e951d' target=_blank 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style='color:#2F92EE;'>#CAR-T#</a>治疗HCC的作用及机制<a href='/topic/show?id=735a81364b7' target=_blank style='color:#2F92EE;'>#肝细胞癌#</a>，这个题目有些扯。如果说观察<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>增强<a href='/topic/show?id=0d3240e64e' target=_blank style='color:#2F92EE;'>#CAR-T细胞治疗#</a>对<a href='/topic/show?id=66c489335e5' target=_blank style='color:#2F92EE;'>#血液肿瘤#</a>的治疗作用可能更靠谱，如果实体瘤，目前也只有BMCA靶点，而且对肝癌也是根本不靠边, objectTitle=基于T细胞亚群分化探讨黄芪多糖促进CAR-T治疗HCC的作用及机制, objectType=nsfc, longId=1044337, objectId=5275104433e32, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/sci/nsfc_show.do?id=5275104433e32, replyNumber=1, likeNumber=187, createdTime=2023-04-16, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=香港, moduleDTOList=[ModuleDTO(moduleId=5275104433e32, moduleTitle=基于T细胞亚群分化探讨黄芪多糖促进CAR-T治疗HCC的作用及机制, moduleType=nsfc, hrefUrl=https://www.medsci.cn/sci/nsfc_show.do?id=5275104433e32)], 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黄芪

2020-05-29

侠胆医心 (审核中...)

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#黄芪#甲苷家族的化合物具备激活#RXRa#和改善线粒体功能的潜能。基于此，研究推测#黄芪甲苷#可能作为RXRa同型二聚体的潜在激活剂。#心力衰竭##心衰# 黄芪作为补气的#中药#，对于心衰等很多慢性疾病有相当好的治疗效果，只是其中的有效成分并不明确。

北京中医药大学揭秘黄芪甲苷III激活RXRa机制，心力衰竭治疗迎来曙光！

2024-12-14发表于威斯康星

梅斯管理员 (审核中...)

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#自噬# #黄芪# #当归# #细胞焦亡# #脑缺血/再灌注损伤# #AMPK/mTOR通路#

J Ethnopharmacol：黄芪-当归药对通过AMPK/mTOR信号通路促进大鼠大脑中动脉闭塞/再灌注后的自噬活性减轻焦亡

2024-10-29发表于上海

梅斯管理员 (审核中...)

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#黄芪# #脑缺血/再灌注损伤#

黄芪-红花如何神奇逆转脑缺血/再灌注损伤：空间代谢组学的惊人发现！

2024-08-20发表于上海

侠胆医心 (审核中...)

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全文收起利用双样本#孟德尔随机化#（MR）研究#肠道微生物#与#肝硬化#之间的潜在因果关系。 #当归#、#丹参#、#茯苓#、#白芍#、#黄芪#、#苍术#为主要药用植物。植物性药物和#肠道菌群#靶向#MAPK1#、VEGFA、#STAT3#、AKT1、RELA、JUN和ESR1治疗#乙型肝炎#肝硬化，它们的联合使用显示出肝硬化治疗的希望。

Front Cell Infect Microbiol：中医药与肠道菌群在肝硬化改善中的融合应用，数据挖掘和孟德尔随机化研究

2023-11-30发表于威斯康星

侠胆医心 (审核中...)

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全文收起 #固本泻浊汤#(GBXZD)是一种在中医指导下用于治疗#慢性肾脏疾病#(CKD)的复方中药，其主要成分为#黄芪#、#党参#、#积雪草#、#丹参#、#菟丝子#、#大黄#。临床研究表明，GBXZD可缓解患者疲劳、恶心等症状，改善肾功能；但其具体作用机制还有待进一步阐明。作用应该具有调节#肠道微生物#，降肌酐的作用

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侠胆医心 (审核中...)

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基于#网络药理学#的#黄芪##四君子汤#治疗#阿尔茨海默病#机制研究

EBCAM:基于网络药理学的黄芪四君子汤治疗阿尔茨海默病机制研究

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侠胆医心 (审核中...)

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#当归补血汤#（#黄芪#（AR）和#当归#（ASR））通过上调APP/PS1小鼠组蛋白H4赖氨酸12#乙酰化#作用改善#线粒体#生物发生和#认知障碍#

J Ethnopharmacol：当归补血汤通过上调APP/PS1小鼠组蛋白H4赖氨酸12乙酰化作用改善线粒体生物发生和认知缺陷

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