Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1804 1
1813 2
1814 8
1820 1
1838 1
1841 1
1848 4
1849 1
1851 1
1857 1
1859 1
1860 2
1863 1
1865 1
1866 2
1868 3
1869 2
1870 1
1871 2
1872 2
1873 3
1875 1
1876 1
1877 2
1879 4
1880 4
1881 3
1882 4
1883 7
1884 5
1886 3
1887 12
1888 5
1889 13
1890 34
1891 38
1892 36
1893 17
1894 22
1895 14
1896 3
1897 3
1898 7
1899 9
1900 11
1901 5
1902 10
1903 7
1904 6
1905 6
1906 6
1907 7
1908 9
1909 4
1910 7
1911 14
1912 4
1913 7
1914 8
1915 10
1916 13
1917 12
1918 1
1919 5
1920 4
1921 10
1922 11
1923 19
1924 13
1925 18
1926 19
1927 26
1928 21
1929 15
1930 20
1931 14
1932 10
1933 6
1934 10
1935 12
1936 15
1937 13
1938 11
1939 15
1940 15
1941 19
1942 22
1943 10
1944 11
1945 317
1946 922
1947 1033
1948 1088
1949 1023
1950 1281
1951 2421
1952 3502
1953 3997
1954 4332
1955 4469
1956 4902
1957 5355
1958 5119
1959 3232
1960 1814
1961 2072
1962 2178
1963 3091
1964 4145
1965 3584
1966 3812
1967 4838
1968 5973
1969 6189
1970 6687
1971 7206
1972 7719
1973 7975
1974 8368
1975 10019
1976 10044
1977 9647
1978 10003
1979 10631
1980 10669
1981 10682
1982 11670
1983 12912
1984 14252
1985 15008
1986 15245
1987 15523
1988 16362
1989 18061
1990 19169
1991 19285
1992 19770
1993 20245
1994 21045
1995 21350
1996 22080
1997 22841
1998 24653
1999 25938
2000 27904
2001 29441
2002 32383
2003 34901
2004 38298
2005 41619
2006 46314
2007 46703
2008 49603
2009 52636
2010 58430
2011 62633
2012 66592
2013 69597
2014 72463
2015 73415
2016 73936
2017 74937
2018 77311
2019 80703
2020 92877
2021 97396
2022 93430
2023 85369
2024 30394

Text availability

Article attribute

Article type

Publication date

Search Results

1,866,899 results

Results by year

Filters applied: . Clear all
Page 1
Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs.
Jacobson KA, Reitman ML. Jacobson KA, et al. Cells. 2020 Apr 13;9(4):956. doi: 10.3390/cells9040956. Cells. 2020. PMID: 32295065 Free PMC article. Review.
The strength of experimental support for an adenosine-related role in a drug's effects varies widely. AR knockout mice are the 'gold standard' method for investigating an AR role, but few drugs have been tested on these mice. Given the interest in AR modulati …
The strength of experimental support for an adenosine-related role in a drug's effects varies widely. AR knockout mice are the …
Role of Chirality in Drugs: An Overview.
Alkadi H, Jbeily R. Alkadi H, et al. Infect Disord Drug Targets. 2018;18(2):88-95. doi: 10.2174/1871526517666170329123845. Infect Disord Drug Targets. 2018. PMID: 28356054 Review.
This article provides an overview about the stereochemistry and its role in drugs, and also, offers approved isolation methods for enantiomeric pairs....
This article provides an overview about the stereochemistry and its role in drugs, and also, offers approved isolation methods for en …
Guiding Drugs to Target-Harboring Organelles: Stretching Drug-Delivery to a Higher Level of Resolution.
Louzoun-Zada S, Jaber QZ, Fridman M. Louzoun-Zada S, et al. Angew Chem Int Ed Engl. 2019 Oct 28;58(44):15584-15594. doi: 10.1002/anie.201906284. Epub 2019 Aug 12. Angew Chem Int Ed Engl. 2019. PMID: 31237741 Review.
This ratio can be increased by directing the drug to the diseased tissue or pathogenic cell. For drugs targeting fungi and malignant cells, the therapeutic window can be further improved by increasing the resolution of drug delivery to the specific organelle that harbors t …
This ratio can be increased by directing the drug to the diseased tissue or pathogenic cell. For drugs targeting fungi and malignant …
Developmental Changes in Pharmacokinetics and Pharmacodynamics.
van den Anker J, Reed MD, Allegaert K, Kearns GL. van den Anker J, et al. J Clin Pharmacol. 2018 Oct;58 Suppl 10:S10-S25. doi: 10.1002/jcph.1284. J Clin Pharmacol. 2018. PMID: 30248190 Review.
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. ...Being able to continuously improve our care of the ill pediatric patient while simultaneously bei …
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, …
Drugs and drug intermediates from fungi: Striving for greener processes.
Sharma M, Sharma R. Sharma M, et al. Crit Rev Microbiol. 2016;42(2):322-38. doi: 10.3109/1040841X.2014.947240. Epub 2014 Aug 27. Crit Rev Microbiol. 2016. PMID: 25159041 Review.
There is an ever-increasing demand of newer and improved drugs from biological sources to cater to the bio-pharmaceutical sector. ...Genome sequence information of various fungal species has opened newer avenues for improved and faster drug targeting and designing. …
There is an ever-increasing demand of newer and improved drugs from biological sources to cater to the bio-pharmaceutical sect …
Targeting Strategies for Tissue-Specific Drug Delivery.
Zhao Z, Ukidve A, Kim J, Mitragotri S. Zhao Z, et al. Cell. 2020 Apr 2;181(1):151-167. doi: 10.1016/j.cell.2020.02.001. Cell. 2020. PMID: 32243788 Free article. Review.
Off-target effects of systemically administered drugs have been a major hurdle in designing therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to enable site-specific drug delivery holds promise in reducing off-target effects, decreasi …
Off-target effects of systemically administered drugs have been a major hurdle in designing therapies with desired efficacy and accep …
Synthetic Approaches to New Drugs Approved During 2016.
Flick AC, Ding HX, Leverett CA, Fink SJ, O'Donnell CJ. Flick AC, et al. J Med Chem. 2018 Aug 23;61(16):7004-7031. doi: 10.1021/acs.jmedchem.8b00260. Epub 2018 Apr 19. J Med Chem. 2018. PMID: 29620889 Review.
New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describe …
New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical e …
Chiral drugs: synopsis.
Brossi A. Brossi A. Med Res Rev. 1994 Nov;14(6):665-91. doi: 10.1002/med.2610140604. Med Res Rev. 1994. PMID: 7830418 Review. No abstract available.
Managing efficacy and toxicity of drugs: Targeted delivery and excretion.
Kundu P, Das S, Chattopadhyay N. Kundu P, et al. Int J Pharm. 2019 Jun 30;565:378-390. doi: 10.1016/j.ijpharm.2019.04.058. Epub 2019 May 7. Int J Pharm. 2019. PMID: 31075437 Review.
Medicine is a natural companion of mankind in the present era for mere survival from the deadly diseases in ever-increasing polluted environments. Hence, in recent years, major focus of pharmaceutical, medicinal and biophysical research has been navigated in exploring and …
Medicine is a natural companion of mankind in the present era for mere survival from the deadly diseases in ever-increasing polluted environ …
Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities.
LaPlante SR, Roux V, Shahout F, LaPlante G, Woo S, Denk MM, Larda ST, Ayotte Y. LaPlante SR, et al. Nat Protoc. 2021 Nov;16(11):5250-5273. doi: 10.1038/s41596-021-00612-3. Epub 2021 Oct 27. Nat Protoc. 2021. PMID: 34707256 Review.
The free-state solution behaviors of drugs profoundly affect their properties. Therefore, it is critical to properly evaluate a drug's unique multiphase equilibrium when in an aqueous enviroment, which can comprise lone molecules, self-associating aggregate s …
The free-state solution behaviors of drugs profoundly affect their properties. Therefore, it is critical to properly evaluate a dr …
1,866,899 results
You have reached the last available page of results. Please see the User Guide for more information.