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Progress towards the Sustainable Development Goals
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Systematic analysis of muscle aging using joint single-cell and single-nucleus sequencing
Skeletal muscle is a highly heterogenous tissue that comprises multiple cell types. Leveraging single-cell and single-nucleus experiments, we systematically mapped the cellular and molecular changes across different skeletal muscle compartments with age. We identify neuromuscular-junction accessory nuclei that may be pivotal in mitigating denervation and uncovered differences between myofiber and myonucleus aging.
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Aging, longevity and age-related diseases
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Plasma proteomic profiles predict future dementia in healthy adults
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A conserved complex lipid signature marks human muscle aging and responds to short-term exercise
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Human skeletal muscle aging atlas
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Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism