Carbon nanotube-based single photon emitters allow for room-temperature operation, but suffer from vanishing indistinguishability due to strong dephasing. Following a theoretical proposal, the authors tackle the problem experimentally by using a cavity to enhance the photon coherence time and the emission spectral density in the regime of incoherent good cavity-coupling.

Controlling the selectivity of the electroreduction of CO₂ to value-added products is challenging. Here, authors use sub-second operando Raman spectroscopy to analyze Cu catalyst surfaces and discover the pivotal role of co-adsorbed OH and CO in enhancing ethanol selectivity.

Damaging energy bursts in a tokamak are a major obstacle to achieving stable high-fusion performance. Here, the authors demonstrate the use of adaptive and machine-learning control to optimize the 3D magnetic field to prevent edge bursts and maximize fusion performance in two different fusion devices, DIII-D and KSTAR.

Surface acoustic wave devices enable modern electronics and are desirable for quantum systems. Here the authors access and control these devices optically, enabling high acoustic quality factors, materials spectroscopy, and hybrid quantum systems.

Despite advances in active drug-targeting for blood-brain barrier penetration, challenges related to brain biodistribution, and drug accumulation persist. Here the authors show a molecular library design centered on cyclic tertiary amine compounds and develop a self-enhanced brain-targeted nucleic acid delivery system inspired by the neuroprotective properties of vinpocetine.

The sources and sinks of Re and U in the modern ocean may be imbalanced, according to sedimentary porewater analysis and assessment of reductive Re and U removal on the continental shelf

Australian estuaries shown to emit more CO₂ per unit area than global estuaries due to the dominance of macrotidal subtropical and tropical tidal systems, while disturbance effects were minimal due to low overall disturbance.

The authors reveal a 3.9% intensification in the sea surface temperature seasonal cycle over the past four decades, with hotspot regions experiencing intensification of up to 10%. This intensification extends throughout the mixed layer, amplifying the seasonal cycle of upper-ocean oxygenation.

Using prey size measurements from ten Southern Ocean lanternfish species sampled across >10° of latitude, this study shows that higher temperatures were associated with smaller fish and an overall decrease in the size of fish relative to their prey. Ocean warming may therefore alter the diversity and size structuring of trophic interactions, reducing the stability of marine ecosystems.

Assumptions about the use of biomass and CO₂ sequestration drive key differences in how emissions from remaining fuels are mitigated in net-zero energy systems, with potentially significant tradeoffs that will need to be evaluated and managed.

NADPH oxidase 5 (NOX5) is activated by Ca²⁺ signaling, catalyzing superoxide production by transferring electrons from intracellular NADPH to extracellular oxygen. Here the authors uncover the molecular basis of NOX5 activation and electron transfer.

Pentamidine and melarsoprol are drugs used to treat sleeping sickness caused by Trypanosoma brucei. Here, authors present cryo-EM structures of TbAQP2 with molecular dynamic simulations, revealing mechanisms shaping substrate specificity and drug permeation.

Greenbeards encode perceptible signals, signal recognition ability, and altruism towards others displaying the signal. This study shows that activation of the greenbeard receptor gene tgrB1 increases altruism and inactivation causes kin-specific cheating in the social amoeba Dictyostelium discoideum.

In this study, the authors detect diverse Ehrlichia and Anaplasma bacteria in samples from Amazonian wildlife, humans and ticks that are mostly distinct from pathogens detected in the Northern Hemisphere and that might indicate emerging health hazards from tick-borne diseases in the Amazon rainforests.

Despite advances in active drug-targeting for blood-brain barrier penetration, challenges related to brain biodistribution, and drug accumulation persist. Here the authors show a molecular library design centered on cyclic tertiary amine compounds and develop a self-enhanced brain-targeted nucleic acid delivery system inspired by the neuroprotective properties of vinpocetine.

High levels of extended spectrum beta-lactamase (ESBL) and carbapenemase encoding genes were detected in bacterial isolates causing neonatal sepsis in LMICs. Authors assess the in vitro activity of three antibiotics (fosfomycin, flomoxef and amikacin) in combination against ESBL-producing Klebsiella pneumoniae and Escherichia coli isolates.

Cardiovascular events are the main cause of mortality in patients with metabolic dysfunctionassociated steatohepatitis (MASH). Here, the authors show that lanifibranor improves cardiometabolic health - insulin sensitivity, lipid and glucose metabolism, systemic inflammation and hepatic steatosis.

While machine learning platforms can improve the assessment of Hematoxylin & Eosin (H&E) stained-tumour tissue images, current models typically require manual cell-type annotations in training. Here, the authors develop VOLTA, a self-supervised machine learning framework to improve cell representation learning in H&E images based on the cells environment

Encephalitis is a rare and severe complication of Herpes Simplex type 1 infection. Here, Bibert et al describe a genetic variant in a 2-year-old affected child that impairs interferon production in neuronal cells and enhances viral replication.

Exponential growth of toxigenic Streptococcus pyogenes M1_UK lineage accounted for most of the 2022/2023 invasive infection upsurge in the UK. Authors provide evidence that M1_UK first emerged in 2008, has genetic evidence of enhanced fitness, and has disseminated to 3 continents.

Human groups preserve cultural history in songs passed between generations. Here the authors show that musical histories are largely independent of the history preserved in genes and languages.

Incorporating spin crossover motifs into mechanically interlocked molecules offers various switchable properties. Here, the authors report two Fe^II catenated metal-organic frameworks that exhibit spin dependent luminescence and dielectric switching.

Assumptions about the use of biomass and CO₂ sequestration drive key differences in how emissions from remaining fuels are mitigated in net-zero energy systems, with potentially significant tradeoffs that will need to be evaluated and managed.

Plastics, chemical production, and fertilizers commonly rely on fossil fuels. Here the authors examine these uses in China and find that in 2017, 5%, 15%, and 7% of China’s total coal, crude oil, and natural gas were used as feedstocks in the chemical industry.

Sustainable agricultural policies need to be practically assessed. Here, the authors assess how management practices affect ecosystem services in Swiss agricultural grasslands showing that organic farming has a lesser impact than the eco-scheme and the use as pasture or meadow.