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Pulmonary toxicity, cytotoxicity, and genotoxicity of submicron-diameter carbon fibers with different diameters and lengths.
Fujita K, Obara S, Maru J. Fujita K, et al. Toxicology. 2022 Jan 30;466:153063. doi: 10.1016/j.tox.2021.153063. Epub 2021 Dec 8. Toxicology. 2022. PMID: 34890706 Free article.
Submicron-diameter carbon fibers (SCFs) are a type of fine-diameter fibrous carbon material that can be used in various applications. ...
Submicron-diameter carbon fibers (SCFs) are a type of fine-diameter fibrous carbon material that can be used in various applications. …
Translocation of particle-laden alveolar macrophages and intra-alveolar granuloma formation in rats exposed to Ludox colloidal amorphous silica by inhalation.
Lee KP, Kelly DP. Lee KP, et al. Toxicology. 1993 Mar 19;77(3):205-22. doi: 10.1016/0300-483x(93)90161-k. Toxicology. 1993. PMID: 8384734
They were characterized by slender cytoplasmic processes, phagosomes, myelin figures (alveolar surfactant), cholesterol clefts and lipid droplets. Many migrated particle-laden AMs were necrotic and released particles in the TBLN. ...However, perivascular silicotic g …
They were characterized by slender cytoplasmic processes, phagosomes, myelin figures (alveolar surfactant), cholesterol clefts and lipid dro …
In vitro assays to predict the pathogenicity of mineral fibers.
Mossman BT, Sesko AM. Mossman BT, et al. Toxicology. 1990 Jan-Feb;60(1-2):53-61. doi: 10.1016/0300-483x(90)90162-a. Toxicology. 1990. PMID: 2156357
In an effort to find alternative approaches to animal testing, cells (rat alveolar macrophages, hamster tracheal epithelial cells, rat lung fibroblasts) of the respiratory tract have been evaluated for cytotoxic and metabolic changes after exposure to fibers (defined as a …
In an effort to find alternative approaches to animal testing, cells (rat alveolar macrophages, hamster tracheal epithelial cells, rat lung …
Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearance.
Warheit DB, Webb TR, Reed KL, Hansen JF, Kennedy GL Jr. Warheit DB, et al. Toxicology. 2003 Nov 5;192(2-3):189-210. doi: 10.1016/s0300-483x(03)00304-4. Toxicology. 2003. PMID: 14580786
This inhalation toxicity study in rats was conducted to assess the hazard potential for workers inhaling Nylon respirable fibers. Groups of 48 male rats each were exposed, nose-only, 6h per day, 5 days per week, for 4 weeks to aerosols of uncoated, finish-free Nylon respir …
This inhalation toxicity study in rats was conducted to assess the hazard potential for workers inhaling Nylon respirable fibers. Gro …
Effects of crocidolite asbestos on human bronchoepithelial-dependent fibroblast stimulation in coculture: the role of IL-6 and GM-CSF.
Lang DS, Schocker H, Hockertz S. Lang DS, et al. Toxicology. 2001 Feb 21;159(1-2):81-98. doi: 10.1016/s0300-483x(00)00415-7. Toxicology. 2001. PMID: 11250057
For this purpose, epithelial cells were pre-exposed to UICC crocidolite asbestos fibers or titanium dioxide (TiO2) particles for 96 h and subsequently cocultured with fibroblasts for additional 72 h. ...
For this purpose, epithelial cells were pre-exposed to UICC crocidolite asbestos fibers or titanium dioxide (TiO2) particles f …
Short-term crocidolite inhalation studies in mice: validation of an inhalation chamber.
Rihn B, Kauffer E, Martin P, Coulais C, Villa M, Bottin MC, Vigneron JC, Edorh A, Martinet N. Rihn B, et al. Toxicology. 1996 May 17;109(2-3):147-56. doi: 10.1016/0300-483x(96)03325-2. Toxicology. 1996. PMID: 8658545
A month later the mice showed typical inflammatory bronchoalveolar liquids with many polynucleated or activated macrophages and asbestos bodies. The burden of crocidolite fibers ranged from 345,000 to 1,300,000 fibers per mg of dried lung. This study demonstrates th …
A month later the mice showed typical inflammatory bronchoalveolar liquids with many polynucleated or activated macrophages and asbestos bod …