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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1940 1
1945 1
1958 1
1961 4
1962 1
1963 1
1964 1
1966 1
1967 2
1968 1
1969 2
1970 2
1971 4
1972 3
1973 8
1974 10
1975 10
1976 5
1977 11
1978 7
1979 9
1980 10
1981 6
1982 3
1983 13
1984 12
1985 12
1986 20
1987 13
1988 20
1989 15
1990 21
1991 16
1992 23
1993 26
1994 23
1995 25
1996 13
1997 20
1998 24
1999 26
2000 40
2001 31
2002 32
2003 24
2004 34
2005 28
2006 48
2007 41
2008 36
2009 37
2010 41
2011 45
2012 42
2013 36
2014 58
2015 32
2016 67
2017 57
2018 61
2019 55
2020 75
2021 69
2022 86
2023 57
2024 36

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1,583 results

Results by year

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Page 1
Mass spectrometry and protein analysis.
Domon B, Aebersold R. Domon B, et al. Science. 2006 Apr 14;312(5771):212-7. doi: 10.1126/science.1124619. Science. 2006. PMID: 16614208 Review.
Driven by the need to identify, characterize, and quantify proteins at ever increasing sensitivity and in ever more complex samples, a wide range of new mass spectrometry-based analytical platforms and experimental strategies have emerged. Here we review recent advances in …
Driven by the need to identify, characterize, and quantify proteins at ever increasing sensitivity and in ever more complex samples, a wide …
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. Hou P, et al. Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278. Epub 2013 Jul 18. Science. 2013. PMID: 23868920 Free article.
However, genetic manipulation and technically challenging strategies such as nuclear transfer used in reprogramming limit their clinical applications. ...By using small molecules, exogenous "master genes" are dispensable for cell fate reprogramming. This chemical reprogram …
However, genetic manipulation and technically challenging strategies such as nuclear transfer used in reprogramming limit their clini …
Swifter, higher, stronger: What's on the menu?
Burke LM, Hawley JA. Burke LM, et al. Science. 2018 Nov 16;362(6416):781-787. doi: 10.1126/science.aau2093. Epub 2018 Nov 15. Science. 2018. PMID: 30442803 Review.
Despite an enduring belief in a single, superior "athletic diet," diversity in sports nutrition practices among successful athletes arises from the specificity of the metabolic demands of different sports and the periodization of training and competition goals. Pragmatic implemen …
Despite an enduring belief in a single, superior "athletic diet," diversity in sports nutrition practices among successful athletes arises f …
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.
Schulze CJ, Seamon KJ, Zhao Y, Yang YC, Cregg J, Kim D, Tomlinson A, Choy TJ, Wang Z, Sang B, Pourfarjam Y, Lucas J, Cuevas-Navarro A, Ayala-Santos C, Vides A, Li C, Marquez A, Zhong M, Vemulapalli V, Weller C, Gould A, Whalen DM, Salvador A, Milin A, Saldajeno-Concar M, Dinglasan N, Chen A, Evans J, Knox JE, Koltun ES, Singh M, Nichols R, Wildes D, Gill AL, Smith JAM, Lito P. Schulze CJ, et al. Science. 2023 Aug 18;381(6659):794-799. doi: 10.1126/science.adg9652. Epub 2023 Aug 17. Science. 2023. PMID: 37590355 Free PMC article.
Proteins that lack this feature are considered undruggable and require innovative strategies for therapeutic targeting. KRAS is the most frequently activated oncogene in cancer, and the active state of mutant KRAS is such a recalcitrant target. ...The resulting CYPA:drug:K …
Proteins that lack this feature are considered undruggable and require innovative strategies for therapeutic targeting. KRAS is the m …
Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies.
Chang CW, Shao E, Mucke L. Chang CW, et al. Science. 2021 Feb 26;371(6532):eabb8255. doi: 10.1126/science.abb8255. Science. 2021. PMID: 33632820 Free PMC article. Review.
This knowledge gap poses major obstacles to the development of truly impactful therapeutic strategies. The current expansion and intensification of efforts to translate mechanistic insights into tau-related therapeutics should address this issue and could deliver better tr …
This knowledge gap poses major obstacles to the development of truly impactful therapeutic strategies. The current expansion and inte …
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease.
Ellebrecht CT, Bhoj VG, Nace A, Choi EJ, Mao X, Cho MJ, Di Zenzo G, Lanzavecchia A, Seykora JT, Cotsarelis G, Milone MC, Payne AS. Ellebrecht CT, et al. Science. 2016 Jul 8;353(6295):179-84. doi: 10.1126/science.aaf6756. Epub 2016 Jun 30. Science. 2016. PMID: 27365313 Free PMC article.
Ideally, therapy for autoimmune diseases should eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible strategies for such an approach have been elusive. Here, we show that in the antibody-mediated autoimmune disease pemphigus vulgaris (PV), …
Ideally, therapy for autoimmune diseases should eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible str …
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Winter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, Bradner JE. Winter GE, et al. Science. 2015 Jun 19;348(6241):1376-81. doi: 10.1126/science.aab1433. Epub 2015 May 21. Science. 2015. PMID: 25999370 Free PMC article.
In part, this is because many small-molecule antagonists disrupt the activity of only one domain in the target protein. We devised a chemical strategy that promotes ligand-dependent target protein degradation using as an example the transcriptional coactivator BRD4, a prot …
In part, this is because many small-molecule antagonists disrupt the activity of only one domain in the target protein. We devised a chemica …
Metaknowledge.
Evans JA, Foster JG. Evans JA, et al. Science. 2011 Feb 11;331(6018):721-5. doi: 10.1126/science.1201765. Science. 2011. PMID: 21311014
We review the expanding scope of metaknowledge research, which uncovers regularities in scientific claims and infers the beliefs, preferences, research tools, and strategies behind those regularities. Metaknowledge research also investigates the effect of knowledge context …
We review the expanding scope of metaknowledge research, which uncovers regularities in scientific claims and infers the beliefs, preference …
Blind spots in biodefense.
Linder A, Jamieson D. Linder A, et al. Science. 2023 Feb 17;379(6633):621. doi: 10.1126/science.adg9237. Epub 2023 Feb 16. Science. 2023. PMID: 36795833
In October, the Biden administration released its National Biodefense Strategy (NBS-22), the first update since the COVID-19 pandemic began. ...
In October, the Biden administration released its National Biodefense Strategy (NBS-22), the first update since the COVID-19 pandemic …
Daniel Kahneman (1934-2024).
Fischhoff B. Fischhoff B. Science. 2024 May 3;384(6695):515. doi: 10.1126/science.adp6405. Epub 2024 May 2. Science. 2024. PMID: 38696551
1,583 results