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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1861 1
1879 1
1884 2
1892 1
1895 1
1907 4
1911 1
1913 1
1914 1
1918 1
1924 1
1929 2
1930 1
1932 1
1934 1
1935 1
1938 1
1940 1
1944 1
1946 1
1947 4
1948 2
1949 5
1950 2
1951 5
1952 3
1953 4
1954 4
1955 2
1956 5
1957 8
1958 4
1959 2
1960 10
1961 5
1962 5
1963 13
1964 32
1965 26
1966 38
1967 50
1968 59
1969 46
1970 57
1971 106
1972 77
1973 61
1974 71
1975 112
1976 124
1977 112
1978 127
1979 122
1980 134
1981 125
1982 124
1983 138
1984 142
1985 151
1986 158
1987 188
1988 157
1989 166
1990 231
1991 224
1992 294
1993 277
1994 313
1995 342
1996 429
1997 481
1998 519
1999 558
2000 764
2001 897
2002 942
2003 1102
2004 1213
2005 1518
2006 1629
2007 1772
2008 1759
2009 1792
2010 1922
2011 1957
2012 2090
2013 2161
2014 2320
2015 2366
2016 2264
2017 2337
2018 2388
2019 2478
2020 2682
2021 2969
2022 2970
2023 2942
2024 1170

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Search Results

50,184 results

Results by year

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Page 1
Roles of peripheral clocks: lessons from the fly.
Yildirim E, Curtis R, Hwangbo DS. Yildirim E, et al. FEBS Lett. 2022 Feb;596(3):263-293. doi: 10.1002/1873-3468.14251. Epub 2021 Dec 16. FEBS Lett. 2022. PMID: 34862983 Free PMC article. Review.
The central clock is located in a small subset of neurons in the brain and drives daily activity rhythms, whereas most peripheral tissues harbor their own clock systems, which generate metabolic and physiological rhythms. Since the discovery of Drosophila melanogast …
The central clock is located in a small subset of neurons in the brain and drives daily activity rhythms, whereas most peripheral tis …
How circadian clocks keep time: the discovery of slowness.
Partch C, Brunner M. Partch C, et al. FEBS Lett. 2022 Jul;596(13):1613-1614. doi: 10.1002/1873-3468.14432. Epub 2022 Jul 1. FEBS Lett. 2022. PMID: 35775878 Free article. Review.
Circadian clocks are molecular timers that measure 24-hour periods through a series of slow but precise biochemical processes. While circadian clocks of cyanobacteria are driven by interactions and ordered phosphorylation of highly structured protein assemblies, tim …
Circadian clocks are molecular timers that measure 24-hour periods through a series of slow but precise biochemical processes. While …
Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics.
Mofatteh M, Echegaray-Iturra F, Alamban A, Dalla Ricca F, Bakshi A, Aydogan MG. Mofatteh M, et al. Elife. 2021 Sep 29;10:e72104. doi: 10.7554/eLife.72104. Elife. 2021. PMID: 34586070 Free PMC article. Review.
Potential answers to these fundamental questions of cell biology have historically revolved around the discussion of 'master' temporal programs, such as the principal cyclin-dependent kinase/cyclin cell division oscillator and the circadian clock. In this review, we provid …
Potential answers to these fundamental questions of cell biology have historically revolved around the discussion of 'master' temporal progr …
It's about time: clocks in the developing lung.
Bartman CM, Matveyenko A, Prakash YS. Bartman CM, et al. J Clin Invest. 2020 Jan 2;130(1):39-50. doi: 10.1172/JCI130143. J Clin Invest. 2020. PMID: 31895049 Free PMC article. Review.
The discovery of peripheral intracellular clocks revealed circadian oscillations of clock genes and their targets in all cell types, including those in the lung, sparking exploration of clocks in lung disease pathophysiology. While the focus has been on the r …
The discovery of peripheral intracellular clocks revealed circadian oscillations of clock genes and their targets in all cell …
Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism.
Verlande A, Masri S. Verlande A, et al. Trends Endocrinol Metab. 2019 Jul;30(7):445-458. doi: 10.1016/j.tem.2019.05.001. Epub 2019 May 30. Trends Endocrinol Metab. 2019. PMID: 31155396 Free PMC article. Review.
The circadian clock is a biological mechanism that dictates an array of rhythmic physiological processes. Virtually all cells contain a functional clock whose disruption results in altered timekeeping and detrimental systemic effects, including cancer. ...
The circadian clock is a biological mechanism that dictates an array of rhythmic physiological processes. Virtually all cells contain …
Molecular Connections Between Circadian Clocks and Aging.
Welz PS, Benitah SA. Welz PS, et al. J Mol Biol. 2020 May 29;432(12):3661-3679. doi: 10.1016/j.jmb.2019.12.036. Epub 2019 Dec 27. J Mol Biol. 2020. PMID: 31887285 Review.
These circadian clock-dependent behavioral and molecular changes in turn further accelerate the process of aging. Here we review the current knowledge about how aging affects the circadian clock, how the functional decline of the circadian clock affects aging …
These circadian clock-dependent behavioral and molecular changes in turn further accelerate the process of aging. Here we review the …
Using Epigenetic Clocks to Characterize Biological Aging in Studies of Children and Childhood Exposures: a Systematic Review.
Musci RJ, Raghunathan RS, Johnson SB, Klein L, Ladd-Acosta C, Ansah R, Hassoun R, Voegtline KM. Musci RJ, et al. Prev Sci. 2023 Oct;24(7):1398-1423. doi: 10.1007/s11121-023-01576-4. Epub 2023 Jul 21. Prev Sci. 2023. PMID: 37477807 Free PMC article. Review.
The use of epigenetic clocks in pediatric research is rapidly increasing, and there is a need to review the landscape of this work to understand the utility of these clocks for prevention scientists. ...While findings were somewhat mixed, a majority of included stud …
The use of epigenetic clocks in pediatric research is rapidly increasing, and there is a need to review the landscape of this work to …
Oscillator networks with tissue-specific circadian clocks in plants.
Inoue K, Araki T, Endo M. Inoue K, et al. Semin Cell Dev Biol. 2018 Nov;83:78-85. doi: 10.1016/j.semcdb.2017.09.002. Epub 2017 Sep 8. Semin Cell Dev Biol. 2018. PMID: 28893605 Review.
In mammals, the circadian clock consists of a central clock in the suprachiasmatic nucleus and peripheral clocks in other tissues. The central clock is tightly coupled to synchronize rhythmicity and can organize peripheral clocks through neural …
In mammals, the circadian clock consists of a central clock in the suprachiasmatic nucleus and peripheral clocks in oth …
Pharmacological Interventions to Circadian Clocks and Their Molecular Bases.
Miller S, Hirota T. Miller S, et al. J Mol Biol. 2020 May 29;432(12):3498-3514. doi: 10.1016/j.jmb.2020.01.003. Epub 2020 Jan 10. J Mol Biol. 2020. PMID: 31931005 Free article. Review.
Daily physiological rhythms are regulated by the body's internal timekeeper known as the circadian clock. Expression, post-translational modification, and degradation of clock proteins constituting the circadian clock are precisely controlled in a rhythmic ma …
Daily physiological rhythms are regulated by the body's internal timekeeper known as the circadian clock. Expression, post-translatio …
Biological Clocks: Why We Need Them, Why We Cannot Trust Them, How They Might Be Improved.
Mitteldorf J. Mitteldorf J. Biochemistry (Mosc). 2024 Feb;89(2):356-366. doi: 10.1134/S0006297924020135. Biochemistry (Mosc). 2024. PMID: 38622101 Free article. Review.
However, extant clocks do not distinguish between type (1) and type (2). Reversing type (1) changes extends lifespan, but reversing type (2) shortens lifespan. This is why all extant epigenetic clocks may be misleading. Separation of type (1) and type (2) epigenetic …
However, extant clocks do not distinguish between type (1) and type (2). Reversing type (1) changes extends lifespan, but reversing t …
50,184 results
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