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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1905 1
1908 1
1911 1
1920 1
1926 1
1928 1
1929 1
1932 1
1933 1
1939 1
1945 1
1946 1
1947 3
1948 3
1949 2
1950 2
1951 2
1952 6
1953 10
1954 8
1955 13
1956 8
1957 10
1958 6
1959 16
1960 19
1961 17
1962 10
1963 9
1964 18
1965 17
1966 36
1967 31
1968 38
1969 54
1970 68
1971 65
1972 71
1973 81
1974 83
1975 283
1976 291
1977 284
1978 283
1979 315
1980 344
1981 353
1982 377
1983 453
1984 524
1985 600
1986 601
1987 610
1988 608
1989 801
1990 916
1991 874
1992 1105
1993 1200
1994 1305
1995 1476
1996 1708
1997 1817
1998 2194
1999 2373
2000 2880
2001 3430
2002 3848
2003 4593
2004 4899
2005 5718
2006 6169
2007 6962
2008 7730
2009 8698
2010 9980
2011 11531
2012 12756
2013 14058
2014 16627
2015 18294
2016 20074
2017 21611
2018 23688
2019 25585
2020 27254
2021 28256
2022 27170
2023 26612
2024 10319

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329,423 results

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Page 1
Recent Advances in the Synthesis of Ibuprofen and Naproxen.
Ha MW, Paek SM. Ha MW, et al. Molecules. 2021 Aug 7;26(16):4792. doi: 10.3390/molecules26164792. Molecules. 2021. PMID: 34443379 Free PMC article. Review.
Herein, we review the recent progress in the synthesis of representative nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen and naproxen. Although these drugs were discovered over 50 years ago, novel practical and asymmetric approaches are still being developed for t …
Herein, we review the recent progress in the synthesis of representative nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen and …
Advances in Fmoc solid-phase peptide synthesis.
Behrendt R, White P, Offer J. Behrendt R, et al. J Pept Sci. 2016 Jan;22(1):4-27. doi: 10.1002/psc.2836. J Pept Sci. 2016. PMID: 26785684 Free PMC article. Review.
Today, Fmoc SPPS is the method of choice for peptide synthesis. Very-high-quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS. ...Improvements are being conti …
Today, Fmoc SPPS is the method of choice for peptide synthesis. Very-high-quality Fmoc building blocks are available at low cost beca …
Emerging therapies in cancer metabolism.
Xiao Y, Yu TJ, Xu Y, Ding R, Wang YP, Jiang YZ, Shao ZM. Xiao Y, et al. Cell Metab. 2023 Aug 8;35(8):1283-1303. doi: 10.1016/j.cmet.2023.07.006. Cell Metab. 2023. PMID: 37557070 Review.
This review summarizes the metabolic targets for cancer treatment and provides an overview of the current status of clinical trials targeting cancer metabolism. Additionally, we decipher crucial factors that limit the efficacy of metabolism-based therapies and propo …
This review summarizes the metabolic targets for cancer treatment and provides an overview of the current status of clinical trials targetin …
Acetyl-CoA metabolism in cancer.
Guertin DA, Wellen KE. Guertin DA, et al. Nat Rev Cancer. 2023 Mar;23(3):156-172. doi: 10.1038/s41568-022-00543-5. Epub 2023 Jan 19. Nat Rev Cancer. 2023. PMID: 36658431 Review.
Efforts to target acetyl-CoA metabolic enzymes are also advancing, with one therapeutic agent targeting acetyl-CoA synthesis receiving approval from the US Food and Drug Administration. In this Review, we give an overview of the regulation and cancer relevance of ma …
Efforts to target acetyl-CoA metabolic enzymes are also advancing, with one therapeutic agent targeting acetyl-CoA synthesis r …
Global view of human protein glycosylation pathways and functions.
Schjoldager KT, Narimatsu Y, Joshi HJ, Clausen H. Schjoldager KT, et al. Nat Rev Mol Cell Biol. 2020 Dec;21(12):729-749. doi: 10.1038/s41580-020-00294-x. Epub 2020 Oct 21. Nat Rev Mol Cell Biol. 2020. PMID: 33087899 Review.
The tremendous structural diversity of glycans attached to proteins poses analytical challenges that limit exploration of specific functions of glycosylation. Major advances in quantitative transcriptomics, proteomics and nuclease-based gene editing are now opening new glo …
The tremendous structural diversity of glycans attached to proteins poses analytical challenges that limit exploration of specific functions …
Peroxisome: Metabolic Functions and Biogenesis.
Okumoto K, Tamura S, Honsho M, Fujiki Y. Okumoto K, et al. Adv Exp Med Biol. 2020;1299:3-17. doi: 10.1007/978-3-030-60204-8_1. Adv Exp Med Biol. 2020. PMID: 33417203 Review.
Peroxisome is an organelle conserved in almost all eukaryotic cells with a variety of functions in cellular metabolism, including fatty acid beta-oxidation, synthesis of ether glycerolipid plasmalogens, and redox homeostasis. Such metabolic functions and the exclusi …
Peroxisome is an organelle conserved in almost all eukaryotic cells with a variety of functions in cellular metabolism, including fat …
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm.
Zhao J, Ye F, Huang P, Wang P. Zhao J, et al. Curr Opin Chem Biol. 2023 Dec;77:102405. doi: 10.1016/j.cbpa.2023.102405. Epub 2023 Oct 26. Curr Opin Chem Biol. 2023. PMID: 37897925 Review.
This review summarizes the recent progress of their synthetic strategies, highlighting the significant advancements in this area....
This review summarizes the recent progress of their synthetic strategies, highlighting the significant advancements in this area....
Synthesis of Anhydroryanodol.
Du K, Kier MJ, Stempel ZD, Jeso V, Rheingold AL, Micalizio GC. Du K, et al. J Am Chem Soc. 2020 Jul 29;142(30):12937-12941. doi: 10.1021/jacs.0c05766. Epub 2020 Jul 7. J Am Chem Soc. 2020. PMID: 32609506 Free PMC article.
A stereoselective entry to ryanoids is described that culminates in the synthesis of anhydroryanodol and thus the formal total synthesis of ryanodol. ...Furthermore, the first application of this technology in natural product synthesis is demonstrated here. M …
A stereoselective entry to ryanoids is described that culminates in the synthesis of anhydroryanodol and thus the formal total syn …
Indirect calorimetry: a practical guide for clinicians.
Haugen HA, Chan LN, Li F. Haugen HA, et al. Nutr Clin Pract. 2007 Aug;22(4):377-88. doi: 10.1177/0115426507022004377. Nutr Clin Pract. 2007. PMID: 17644692 Review.
This review provides clinicians with a comprehensive overview of indirect calorimetry including the principles, methodology, technologic advancements, benefits, and challenges. Clinical applications for indirect calorimetry and the potential limitations are specifically ad …
This review provides clinicians with a comprehensive overview of indirect calorimetry including the principles, methodology, technologic …
Toward Automated Enzymatic Synthesis of Oligosaccharides.
Wen L, Edmunds G, Gibbons C, Zhang J, Gadi MR, Zhu H, Fang J, Liu X, Kong Y, Wang PG. Wen L, et al. Chem Rev. 2018 Sep 12;118(17):8151-8187. doi: 10.1021/acs.chemrev.8b00066. Epub 2018 Jul 16. Chem Rev. 2018. PMID: 30011195 Review.
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide synthesis have significantly advanced developments in biological science by allowing non …
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major classes of natural biopolymers. Automated systems …
329,423 results
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