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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1955 1
1956 2
1957 10
1958 16
1959 16
1960 23
1961 29
1962 29
1963 46
1964 81
1965 73
1966 113
1967 118
1968 174
1969 170
1970 248
1971 267
1972 305
1973 367
1974 541
1975 648
1976 717
1977 831
1978 892
1979 1002
1980 1242
1981 1492
1982 1879
1983 1983
1984 2436
1985 3081
1986 3554
1987 4051
1988 4823
1989 5758
1990 6654
1991 7627
1992 8495
1993 9412
1994 10638
1995 11618
1996 12638
1997 13128
1998 14134
1999 15032
2000 16471
2001 16913
2002 17476
2003 17832
2004 18512
2005 19995
2006 20961
2007 21801
2008 22825
2009 23500
2010 24680
2011 26164
2012 27739
2013 28364
2014 28824
2015 29459
2016 28919
2017 29023
2018 29044
2019 29421
2020 31280
2021 31676
2022 28070
2023 25089
2024 10315

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685,541 results

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Page 1
Cytokine Regulation and Function in T Cells.
Dong C. Dong C. Annu Rev Immunol. 2021 Apr 26;39:51-76. doi: 10.1146/annurev-immunol-061020-053702. Epub 2021 Jan 11. Annu Rev Immunol. 2021. PMID: 33428453
T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune responses to mediate inflammation and regulate other types of immune cells. ...Mechanisms exist to prevent cytokine production by T cells to maintai …
T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune responses to mediate inflamma …
Strategies to therapeutically modulate cytokine action.
Leonard WJ, Lin JX. Leonard WJ, et al. Nat Rev Drug Discov. 2023 Oct;22(10):827-854. doi: 10.1038/s41573-023-00746-x. Epub 2023 Aug 4. Nat Rev Drug Discov. 2023. PMID: 37542128 Review.
Cytokines are secreted or membrane-presented molecules that mediate broad cellular functions, including development, differentiation, growth and survival. ...In modulating the actions of cytokines, the strategies used have been broad, including altering affin …
Cytokines are secreted or membrane-presented molecules that mediate broad cellular functions, including development, different …
Insights into cytokine-receptor interactions from cytokine engineering.
Spangler JB, Moraga I, Mendoza JL, Garcia KC. Spangler JB, et al. Annu Rev Immunol. 2015;33:139-67. doi: 10.1146/annurev-immunol-032713-120211. Epub 2014 Dec 10. Annu Rev Immunol. 2015. PMID: 25493332 Free PMC article. Review.
However, the desired immunotherapeutic effects of native cytokines are often mitigated by toxicity or lack of efficacy, either of which results from cytokine receptor pleiotropy and/or undesired activation of off-target cells. ...We discuss specific examples …
However, the desired immunotherapeutic effects of native cytokines are often mitigated by toxicity or lack of efficacy, either of whi …
Cytokines and cellular crosstalk involved in the activation of fat-storing cells.
Gressner AM. Gressner AM. J Hepatol. 1995;22(2 Suppl):28-36. J Hepatol. 1995. PMID: 7665846 Review.
Based on current knowledge a "3-step cascade model of fat-storing cell activation" is suggested, which implies sequential cross-talk between fat-storing cells, hepatocytes, Kupffer cells, thrombocytes, endothelial cells, and myofibroblasts (transformed fat-st …
Based on current knowledge a "3-step cascade model of fat-storing cell activation" is suggested, which implies sequential cross-talk between …
Advances in the regulation of osteoclasts and osteoclast functions.
Boyce BF. Boyce BF. J Dent Res. 2013 Oct;92(10):860-7. doi: 10.1177/0022034513500306. Epub 2013 Aug 1. J Dent Res. 2013. PMID: 23906603 Free PMC article. Review.
These circulating precursors are attracted to bone surfaces undergoing resorption by chemokines and other factors expressed at these sites, where they fuse to form multinucleated bone-resorbing cells. All aspects of osteoclast formation and functions are regulated by macro …
These circulating precursors are attracted to bone surfaces undergoing resorption by chemokines and other factors expressed at these sites, …
Cytokines and Pancreatic beta-Cell Apoptosis.
Berchtold LA, Prause M, Størling J, Mandrup-Poulsen T. Berchtold LA, et al. Adv Clin Chem. 2016;75:99-158. doi: 10.1016/bs.acc.2016.02.001. Epub 2016 Apr 20. Adv Clin Chem. 2016. PMID: 27346618 Review.
Due to the considerable translational importance of enhancing the precision, specificity, and safety of antiinflammatory treatments of diabetes, we review here the cellular, preclinical, and clinical evidence of which of the death pathways recently proposed in the Nomencla …
Due to the considerable translational importance of enhancing the precision, specificity, and safety of antiinflammatory treatments of diabe …
Insights into the cellular pathophysiology of familial hemophagocytic lymphohistiocytosis.
Steen EA, Nichols KE, Meyer LK. Steen EA, et al. Front Immunol. 2023 Mar 9;14:1147603. doi: 10.3389/fimmu.2023.1147603. eCollection 2023. Front Immunol. 2023. PMID: 36969228 Free PMC article. Review.
Consequently, there is sustained lymphocyte activation, resulting in the secretion of excessive amounts of pro-inflammatory cytokines that further activate other cells of the innate and adaptive immune systems. Together, these activated cells and pro-inflamma …
Consequently, there is sustained lymphocyte activation, resulting in the secretion of excessive amounts of pro-inflammatory cytokines …
Cytokines and proteoglycans.
Nietfeld JJ, Huber-Bruning O, Bÿlsma JW. Nietfeld JJ, et al. EXS. 1994;70:215-42. doi: 10.1007/978-3-0348-7545-5_13. EXS. 1994. PMID: 8298248 Review.
Especially in a tissue like cartilage without any blood vessels, the cells are dependent on cytokines for the communication among themselves in the extra-cellular matrix and also for communication with the 'outside world'. ...So the proteoglycans are clearly …
Especially in a tissue like cartilage without any blood vessels, the cells are dependent on cytokines for the communication am …
Modulation of cytokine function by heparan sulfate proteoglycans: sophisticated models for the regulation of cellular responses to cytokines.
Tanaka Y, Kimata K, Adams DH, Eto S. Tanaka Y, et al. Proc Assoc Am Physicians. 1998 Mar-Apr;110(2):118-25. Proc Assoc Am Physicians. 1998. PMID: 9542767 Review.
The ability of some cytokines to blind to and be immobilized by heparan sulfate proteoglycan (HS-PG) on either the surface of cells or within the extracellular matrix accentuates their action by 1) promoting the accumulation of cytokines at high concentration …
The ability of some cytokines to blind to and be immobilized by heparan sulfate proteoglycan (HS-PG) on either the surface of cell …
Cytokines and neuronal differentiation.
Mehler MF, Kessler JA. Mehler MF, et al. Crit Rev Neurobiol. 1995;9(4):419-46. Crit Rev Neurobiol. 1995. PMID: 8829854 Review.
The exponential growth in the identification and physiological analysis of TGF beta subclasses of cytokines that transduce intracellular signals through intrinsic membrane serine/threonine kinase-associated receptor subunits has led to an increased understanding of their c …
The exponential growth in the identification and physiological analysis of TGF beta subclasses of cytokines that transduce intracellu …
685,541 results
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