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The Molecular Design Research Network.
Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SM, Mellor KE, Corrales J, Kristofco LA, Saari GN, Steele B, Shen LQ, Melnikov F, Zimmerman JB, Anastas PT. Coish P, et al. Toxicol Sci. 2018 Feb 1;161(2):241-248. doi: 10.1093/toxsci/kfx175. Toxicol Sci. 2018. PMID: 28973416 Review.
Herein, we provide an overview of a research network that is aimed at fostering interdisciplinary collaboration between chemists and toxicologists with the goal of rationally designing safer commercial chemicals. The collaborative is the Molecular Design Rese …
Herein, we provide an overview of a research network that is aimed at fostering interdisciplinary collaboration between chemists and toxicol …
Rapid and simple method of qPCR primer design.
Thornton B, Basu C. Thornton B, et al. Methods Mol Biol. 2015;1275:173-9. doi: 10.1007/978-1-4939-2365-6_13. Methods Mol Biol. 2015. PMID: 25697660
Some of the popular reporter systems used in qPCR are the following: Molecular Beacon(), SYBR Green(), and Taqman(). ...Freely available software could be used for ideal qPCR primer design. Here we have shown how to use some freely available web-based softwar …
Some of the popular reporter systems used in qPCR are the following: Molecular Beacon(), SYBR Green(), and Taqman(). ...Freely …
Nucleic Acid Molecular Systems for In Vitro Detection of Biomolecules.
Yang D, Yang L, Wang P. Yang D, et al. ACS Mater Au. 2022 Nov 22;3(2):83-87. doi: 10.1021/acsmaterialsau.2c00056. eCollection 2023 Mar 8. ACS Mater Au. 2022. PMID: 38089727 Free PMC article. Review.
Molecular systems composed of information-rich nucleic acids have emerged as one of the most robust materials due to their programmability, editability, and designability. ...The perspective concludes with perspectives and outlooks to tackle a variety of tech …
Molecular systems composed of information-rich nucleic acids have emerged as one of the most robust materials due to their pro …
DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.
Urban DJ, Roth BL. Urban DJ, et al. Annu Rev Pharmacol Toxicol. 2015;55:399-417. doi: 10.1146/annurev-pharmtox-010814-124803. Epub 2014 Sep 25. Annu Rev Pharmacol Toxicol. 2015. PMID: 25292433 Review.
In the past decade, emerging synthetic biology technologies such as chemogenetics have dramatically transformed how pharmacologists and systems biologists deconstruct the involvement of G protein-coupled receptors (GPCRs) in a myriad of physiological and translational sett …
In the past decade, emerging synthetic biology technologies such as chemogenetics have dramatically transformed how pharmacologists and s …
Human-in-the-loop assisted de novo molecular design.
Sundin I, Voronov A, Xiao H, Papadopoulos K, Bjerrum EJ, Heinonen M, Patronov A, Kaski S, Engkvist O. Sundin I, et al. J Cheminform. 2022 Dec 28;14(1):86. doi: 10.1186/s13321-022-00667-8. J Cheminform. 2022. PMID: 36578043 Free PMC article.
A de novo molecular design workflow can be used together with technologies such as reinforcement learning to navigate the chemical space. A bottleneck in the workflow that remains to be solved is how to integrate human feedback in the exploration of the chemical spa …
A de novo molecular design workflow can be used together with technologies such as reinforcement learning to navigate the chem …
Polymeric materials for immune engineering: Molecular interaction to biomaterial design.
Soni SS, Rodell CB. Soni SS, et al. Acta Biomater. 2021 Oct 1;133:139-152. doi: 10.1016/j.actbio.2021.01.016. Epub 2021 Jan 20. Acta Biomater. 2021. PMID: 33484909 Review.
Importantly, the development of the immune response to polymeric biomaterials spans length scales - from single molecular interactions to the complex sensing of bulk biophysical properties, all of which coordinate a tissue- and systems-level response. In this review …
Importantly, the development of the immune response to polymeric biomaterials spans length scales - from single molecular interaction …
Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry.
Deprez B, Bosc D, Charton J, Couturier C, Deprez-Poulain R, Flipo M, Leroux F, Villemagne B, Willand N. Deprez B, et al. Molecules. 2021 Oct 8;26(19):6083. doi: 10.3390/molecules26196083. Molecules. 2021. PMID: 34641626 Free PMC article. Review.
The former is an interventional science that aims at understanding living systems through the modulation of its molecular components with compounds designed for this purpose. The latter is the art of designing drug candidates, i.e., molecules that act …
The former is an interventional science that aims at understanding living systems through the modulation of its molecular comp …
Walking molecules.
von Delius M, Leigh DA. von Delius M, et al. Chem Soc Rev. 2011 Jul;40(7):3656-76. doi: 10.1039/c1cs15005g. Epub 2011 Mar 17. Chem Soc Rev. 2011. PMID: 21416072 Review.
DNA-walker migration that continues as long as a complex DNA fuel is present--has been demonstrated and sophisticated tasks performed, such as moving gold nanoparticles from place-to-place and assistance in sequential chemical synthesis. Small-molecule systems, an order of …
DNA-walker migration that continues as long as a complex DNA fuel is present--has been demonstrated and sophisticated tasks performed, such …
Architectonics: Design of Molecular Architecture for Functional Applications.
Avinash MB, Govindaraju T. Avinash MB, et al. Acc Chem Res. 2018 Feb 20;51(2):414-426. doi: 10.1021/acs.accounts.7b00434. Epub 2018 Jan 24. Acc Chem Res. 2018. PMID: 29364649
This concept of designing noncovalent systems enables to focus on different functional aspects of designer molecules for biological and nonbiological applications and also strengthens our efforts toward the mastery over the art of controlled molecular …
This concept of designing noncovalent systems enables to focus on different functional aspects of designer molecules fo …
Rational Design of Memory-Based Sensors: the Case of Molecular Calorimeters.
Nwokolo OA, Kidd B, Allen T, Minasyan AS, Vardelly S, Johnson KD, Nesterova IV. Nwokolo OA, et al. Angew Chem Int Ed Engl. 2021 Jan 18;60(3):1610-1614. doi: 10.1002/anie.202011422. Epub 2020 Nov 18. Angew Chem Int Ed Engl. 2021. PMID: 32996657
Thermodynamic characterization is crucial for understanding molecular interactions. However, methodologies for measuring heat changes in small open systems are extremely limited. We document a new approach for designing molecular sensors, that function …
Thermodynamic characterization is crucial for understanding molecular interactions. However, methodologies for measuring heat changes …
74,317 results
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