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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 4
2005 3
2006 6
2007 2
2008 1
2012 1
2013 9
2014 5
2015 15
2016 2
2017 8
2018 4
2019 4
2020 2
2021 5
2024 0

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70 results

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Page 1
Ion channel profiling to advance drug discovery and development.
Zou B. Zou B. Drug Discov Today Technol. 2015 Nov;18:18-23. doi: 10.1016/j.ddtec.2015.10.003. Epub 2015 Nov 3. Drug Discov Today Technol. 2015. PMID: 26723888 Review.
In vitro pharmacological profiling provides crucial information to eliminate drug candidates with potential toxicity early in drug discovery and reduce failure in later stages. It has become a common practice in industry to test lead compounds against a panel of ion …
In vitro pharmacological profiling provides crucial information to eliminate drug candidates with potential toxicity early in drug …
Preface.
Ma H. Ma H. Drug Discov Today Technol. 2015 Nov;18:50-1. doi: 10.1016/j.ddtec.2015.10.009. Epub 2015 Nov 6. Drug Discov Today Technol. 2015. PMID: 26723892 No abstract available.
Translational PK/PD of anti-infective therapeutics.
Rathi C, Lee RE, Meibohm B. Rathi C, et al. Drug Discov Today Technol. 2016 Sep-Dec;21-22:41-49. doi: 10.1016/j.ddtec.2016.08.004. Epub 2016 Oct 28. Drug Discov Today Technol. 2016. PMID: 27978987 Free PMC article. Review.
Translational PK/PD modeling has emerged as a critical technique for quantitative analysis of the relationship between dose, exposure and response of antibiotics. ...Fine-tuning of these basic model structures allows to further account for complicating factors such as resi …
Translational PK/PD modeling has emerged as a critical technique for quantitative analysis of the relationship between dose, exposure …
In vitro functional characterization of biosimilar therapeutic antibodies.
Láng JA, Balogh ZC, Nyitrai MF, Juhász C, Gilicze AKB, Iliás A, Zólyomi Z, Bodor C, Rábai E. Láng JA, et al. Drug Discov Today Technol. 2020 Dec;37:41-50. doi: 10.1016/j.ddtec.2020.11.010. Epub 2020 Dec 11. Drug Discov Today Technol. 2020. PMID: 34895654 Review.
Establishment of a scientifically sound molecule-specific functional in vitro assay panel requires diligent planning and high flexibility in order to respond to both regulatory requirements and the ever-changing demands relevant to the different stages of the developmen …
Establishment of a scientifically sound molecule-specific functional in vitro assay panel requires diligent planning and high flexibi …
Software aided approaches to structure-based metabolite identification in drug discovery and development.
Pähler A, Brink A. Pähler A, et al. Drug Discov Today Technol. 2013 Spring;10(1):e207-17. doi: 10.1016/j.ddtec.2012.12.001. Drug Discov Today Technol. 2013. PMID: 24050249 Review.
Likewise, emerging new technologies in postacquisition data analysis like mass defect filtering (MDF) have moved the technology driven analytical methodology to metabolite identification toward generic, structure-based workflows. The biggest challenge for automation howeve …
Likewise, emerging new technologies in postacquisition data analysis like mass defect filtering (MDF) have moved the technology drive …
Profiling technologies for the identification and characterization of small-molecule histone deacetylase inhibitors.
Liao D. Liao D. Drug Discov Today Technol. 2015 Nov;18:24-8. doi: 10.1016/j.ddtec.2015.10.006. Epub 2015 Nov 3. Drug Discov Today Technol. 2015. PMID: 26723889 Free PMC article. Review.
Histone deacetylases (HDACs) are promising drug targets for treating cancer, neurologic, inflammatory and metabolic diseases. ...
Histone deacetylases (HDACs) are promising drug targets for treating cancer, neurologic, inflammatory and metabolic diseases. ...
Protein kinase profiling assays: a technology review.
Wang Y, Ma H. Wang Y, et al. Drug Discov Today Technol. 2015 Nov;18:1-8. doi: 10.1016/j.ddtec.2015.10.007. Epub 2015 Oct 31. Drug Discov Today Technol. 2015. PMID: 26723886 Review.
Protein kinases have become one of the most intensively pursued classes of drug targets for many diseases such as cancers and inflammatory diseases. ...Many screening assays and technologies which are compatible for high-throughput screening (HTS) against kinases ha …
Protein kinases have become one of the most intensively pursued classes of drug targets for many diseases such as cancers and inflamm …
Screening and profiling assays for HDACs and sirtuins.
Howitz KT. Howitz KT. Drug Discov Today Technol. 2015 Nov;18:38-48. doi: 10.1016/j.ddtec.2015.10.008. Epub 2015 Nov 6. Drug Discov Today Technol. 2015. PMID: 26723891 Review.
Due to their important effects on gene expression and involvement in various disease states, these enzymes have been the subjects of many assay development efforts in recent years. Commonly used techniques include mass spectrometry, antibody-based methods and protea …
Due to their important effects on gene expression and involvement in various disease states, these enzymes have been the subjects of many …
Challenges in profiling and lead optimization of drug discovery for methyltransferases.
Horiuchi KY. Horiuchi KY. Drug Discov Today Technol. 2015 Nov;18:62-8. doi: 10.1016/j.ddtec.2015.10.010. Epub 2015 Nov 21. Drug Discov Today Technol. 2015. PMID: 26723894 Review.
The importance of epigenetics in the initiation and progression of disease has attracted many investigators to incorporate this novel and exciting field in drug development. Protein methyltransferases are one of the target classes which have gained attention as pote …
The importance of epigenetics in the initiation and progression of disease has attracted many investigators to incorporate this novel and ex …
MALDI mass Spectrometry based proteomics for drug discovery & development.
Zubair F. Zubair F. Drug Discov Today Technol. 2021 Dec;40:29-35. doi: 10.1016/j.ddtec.2021.09.002. Epub 2021 Oct 23. Drug Discov Today Technol. 2021. PMID: 34916018
Matrix-assisted laser desorption/ ionization (MALDI) is a soft ionization technique for introducing wide range of analytes into a mass spectrometer (MS). MALDI MS is a powerful tool in drug discovery research and development, providing a high-throughput molecular …
Matrix-assisted laser desorption/ ionization (MALDI) is a soft ionization technique for introducing wide range of analytes into a mass spect …
70 results