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Polymer Nanodiscs and Their Bioanalytical Potential.
Farrelly MD, Martin LL, Thang SH. Farrelly MD, et al. Chemistry. 2021 Sep 9;27(51):12922-12939. doi: 10.1002/chem.202101572. Epub 2021 Jul 30. Chemistry. 2021. PMID: 34180107 Review.
The expanding range of reported amphipathic polymer nanodisc materials is presented and discussed in terms of their tolerance to different solution conditions and their nanodisc properties. Finally, the analytical scope of polymer nanodiscs is considered in both the demons …
The expanding range of reported amphipathic polymer nanodisc materials is presented and discussed in terms of their tolerance to different s …
Studying protein structure and function by native separation-mass spectrometry.
van Schaick G, Haselberg R, Somsen GW, Wuhrer M, Domínguez-Vega E. van Schaick G, et al. Nat Rev Chem. 2022 Mar;6(3):215-231. doi: 10.1038/s41570-021-00353-7. Epub 2022 Jan 20. Nat Rev Chem. 2022. PMID: 37117432 Review.
Alterations in protein structure may have profound effects on biological function. Analytical techniques that permit characterization of proteins while maintaining their conformational and functional state are crucial for studying changes in the higher order structure of p …
Alterations in protein structure may have profound effects on biological function. Analytical techniques that permit characterization …
PET Imaging of Self-Assembled 18 F-Labelled Pd2 L4 Metallacages for Anticancer Drug Delivery.
Cosialls R, Simó C, Borrós S, Gómez-Vallejo V, Schmidt C, Llop J, Cuenca AB, Casini A. Cosialls R, et al. Chemistry. 2023 Jan 12;29(3):e202202604. doi: 10.1002/chem.202202604. Epub 2022 Nov 23. Chemistry. 2023. PMID: 36239701 Free PMC article.
To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of (18) F-labelled [Pd(2) L(4) ](4+) metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the ho …
To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of (18) F-la …
Nano-conjugate fluorescence probe for the discrimination of phosphate and pyrophosphate.
Kim IB, Han MH, Phillips RL, Samanta B, Rotello VM, Zhang ZJ, Bunz UH. Kim IB, et al. Chemistry. 2009;15(2):449-56. doi: 10.1002/chem.200801403. Chemistry. 2009. PMID: 19034949
We can discern >40 nM PPi in the presence of 0.1 mM Pi at pH 7, which suggests that these assemblies may be useful in bio-analytical applications. This displacement assay was used to effectively determine the ability of pyrophosphatase to hydrolyze PPi to Pi....
We can discern >40 nM PPi in the presence of 0.1 mM Pi at pH 7, which suggests that these assemblies may be useful in bio-analytical
All-in-One: Electroactive Nanocarbon as Simultaneous Platform and Label for Single-Step Biosensing.
Cheng ZX, Bonanni A. Cheng ZX, et al. Chemistry. 2018 Apr 25;24(24):6380-6385. doi: 10.1002/chem.201705729. Epub 2018 Feb 6. Chemistry. 2018. PMID: 29315887
We show that the use of electroactive nanocarbon as all-in-one biosensing component enables sensitive quantification of Fumonisin B(1) (FB(1) ) as model mycotoxin analyte, but it can be easily implemented to develop label-free, cost-effective and fast bioanalytical
We show that the use of electroactive nanocarbon as all-in-one biosensing component enables sensitive quantification of Fumonisin B(1) (FB(1 …