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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 2
1951 1
1953 6
1954 8
1955 9
1956 2
1957 6
1958 10
1959 21
1960 28
1961 22
1962 25
1963 25
1964 60
1965 47
1966 33
1967 47
1968 75
1969 104
1970 94
1971 135
1972 161
1973 156
1974 197
1975 252
1976 225
1977 311
1978 265
1979 346
1980 491
1981 609
1982 761
1983 635
1984 807
1985 922
1986 930
1987 1042
1988 1083
1989 1138
1990 1307
1991 1694
1992 1771
1993 1887
1994 2123
1995 2474
1996 2582
1997 2484
1998 2495
1999 2834
2000 3082
2001 3509
2002 3440
2003 3832
2004 4170
2005 4366
2006 4640
2007 4908
2008 4889
2009 4985
2010 5350
2011 5759
2012 6073
2013 6209
2014 6249
2015 5983
2016 5402
2017 5176
2018 5007
2019 4759
2020 6108
2021 6390
2022 4475
2023 2954
2024 1415

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139,049 results

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Page 1
Medicinal chemistry insights into antiviral peptidomimetics.
Ding D, Xu S, da Silva-Júnior EF, Liu X, Zhan P. Ding D, et al. Drug Discov Today. 2023 Mar;28(3):103468. doi: 10.1016/j.drudis.2022.103468. Epub 2022 Dec 14. Drug Discov Today. 2023. PMID: 36528280 Review.
The (re)emergence of multidrug-resistant viruses and the emergence of new viruses highlight the urgent and ongoing need for new antiviral agents. The use of peptidomimetics as therapeutic drugs has often been associated with advantages, such as enhanced binding affi …
The (re)emergence of multidrug-resistant viruses and the emergence of new viruses highlight the urgent and ongoing need for new antiviral …
Medicinal chemistry strategies toward host targeting antiviral agents.
Ji X, Li Z. Ji X, et al. Med Res Rev. 2020 Sep;40(5):1519-1557. doi: 10.1002/med.21664. Epub 2020 Feb 14. Med Res Rev. 2020. PMID: 32060956 Free PMC article. Review.
Direct-acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and have been demonstrated to be very successful in combating viral infections in clinic. ...In comparison, host targeting antivirals (HTAs) target host factors for a …
Direct-acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and have been demonstrated to be ver …
Molecular Mechanisms of Antiviral Agents against Dengue Virus.
Lee MF, Wu YS, Poh CL. Lee MF, et al. Viruses. 2023 Mar 8;15(3):705. doi: 10.3390/v15030705. Viruses. 2023. PMID: 36992414 Free PMC article. Review.
Various antiviral agents have been developed and investigated for their anti-DENV activities. This review discusses the mechanisms of action employed by various antiviral agents against DENV. The development of host-directed antivirals targeting …
Various antiviral agents have been developed and investigated for their anti-DENV activities. This review discusses the mechan …
Medicinal chemistry strategies toward broad-spectrum antiviral agents to prevent next pandemics.
Lü Z, Dai X, Xu J, Liu Z, Guo Y, Gao Z, Meng F. Lü Z, et al. Eur J Med Chem. 2024 May 5;271:116442. doi: 10.1016/j.ejmech.2024.116442. Epub 2024 Apr 25. Eur J Med Chem. 2024. PMID: 38685143 Review.
The pandemic and tremendous impact of severe acute respiratory syndrome coronavirus 2 alert us, despite great achievements in prevention and control of infectious diseases, we still lack universal and powerful antiviral strategies to rapidly respond to the potential threat …
The pandemic and tremendous impact of severe acute respiratory syndrome coronavirus 2 alert us, despite great achievements in prevention and …
Small-molecule oligonucleotides as smart modality for antiviral therapy: a medicinal chemistry perspective.
Kar SS, Dhar AK, Palei NN, Bhatt S. Kar SS, et al. Future Med Chem. 2023 Jun;15(12):1091-1110. doi: 10.4155/fmc-2023-0091. Epub 2023 Aug 16. Future Med Chem. 2023. PMID: 37584172 Review.
The most challenging aspect of these oligonucleotides' therapeutic success involves their delivery. Thus medicinal chemistry strategies are inevitable to avoid degradation by serum nucleases, avoid kidney clearance and improve cellular uptake. ...
The most challenging aspect of these oligonucleotides' therapeutic success involves their delivery. Thus medicinal chemistry strategi …
Norovirus antivirals: Where are we now?
Netzler NE, Enosi Tuipulotu D, White PA. Netzler NE, et al. Med Res Rev. 2019 May;39(3):860-886. doi: 10.1002/med.21545. Epub 2018 Dec 25. Med Res Rev. 2019. PMID: 30584800 Free PMC article. Review.
Yet despite significant research efforts, approved vaccines or antivirals to combat this pathogen are still lacking. Safe and effective antivirals are not available, particularly for chronically infected immunocompromised individuals, and for prophylactic applicatio …
Yet despite significant research efforts, approved vaccines or antivirals to combat this pathogen are still lacking. Safe and effecti …
Process Chemistry in Antiviral Research.
Zhong YL, Yasuda N, Li H, McLaughlin M, Tschaen D. Zhong YL, et al. Top Curr Chem (Cham). 2016 Dec;374(6):77. doi: 10.1007/s41061-016-0076-5. Epub 2016 Nov 2. Top Curr Chem (Cham). 2016. PMID: 27807768 Review.
This article reviews antiviral therapies that have been approved for human use during the last decade, with a focus on the process chemistry that enabled access to these important drugs. In particular, process chemistry highlights from the practical syntheses …
This article reviews antiviral therapies that have been approved for human use during the last decade, with a focus on the process …
2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph.
Meanwell NA. Meanwell NA. J Med Chem. 2016 Aug 25;59(16):7311-51. doi: 10.1021/acs.jmedchem.6b00915. Epub 2016 Aug 8. J Med Chem. 2016. PMID: 27501244 Review.
The development of direct-acting antiviral agents that can cure a chronic hepatitis C virus (HCV) infection after 8-12 weeks of daily, well-tolerated therapy has revolutionized the treatment of this insidious disease. ...A clinical study with 64 and 117 established …
The development of direct-acting antiviral agents that can cure a chronic hepatitis C virus (HCV) infection after 8-12 weeks o …
Dual action anti-inflammatory/antiviral isoquinoline alkaloids as potent naturally occurring anti-SARS-CoV-2 agents: A combined pharmacological and medicinal chemistry perspective.
Valipour M, Hosseini A, Di Sotto A, Irannejad H. Valipour M, et al. Phytother Res. 2023 May;37(5):2168-2186. doi: 10.1002/ptr.7833. Epub 2023 Apr 11. Phytother Res. 2023. PMID: 37039761 Review.
In the present review, our pharmacological and medicinal chemistry evaluation resulted in highlighting the potential of anti-SARS-CoV-2 isoquinoline-based alkaloids for the treatment of COVID-19 patients. Considering critical parameters of the antiviral and anti-inf …
In the present review, our pharmacological and medicinal chemistry evaluation resulted in highlighting the potential of anti-SARS-CoV …
139,049 results
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