Thorax:环境暴露和高血压是肺功能下降的危险因素

2018-08-03 xing.T MedSci原创

由此可见,城市化、生活在高海拔地区和身患高血压与每日吸烟率低人群的肺功能衰退加速有关。

慢性肺疾病是导致全球疾病负担的主要原因;然而,除香烟外,研究人员尚不完全了解哪些危险因素会导致低收入和中等收入国家人群的肺功能下降。

近日,胸部疾病领域权威杂志Thorax上发表了一篇研究文章,研究人员从秘鲁四个资源贫乏地区的3048名年龄≥35岁的成年人中随机抽取年龄分层、性别分层和地区分层的人群样本并收集其社会人口统计学和临床数据。研究人员评估了3年内基线和年度支气管扩张剂前后的肺功能。研究人员使用线性混合效应模型来评估与加速肺功能下降相关的生物、社会经济和环境危险因素。

受试者平均年龄±SD为55.4±12.5岁,男性为49.2%,平均随访时间为2.36(标准差为0.61)年。平均年度给予支气管扩张剂前FEV1下降为30.3 mL/年(95%CI为28.6-32.0),给予支气管扩张剂前FVC下降为32.2mL/年(30.0-34.4)。使用多变量线性混合效应回归分析,研究人员发现城市生活、高海拔居住环境和高血压占给予支气管扩张剂前FEV1/身高2比值的总体平均年降幅分别为25.9%(95%CI为15.7%-36.1%)、21.3%(11.1%-31.5%)和15.7%(3.7%-26.9%)。给与支气管扩张剂前相应的FVC/身高2比值的估计值分别为42.1%(95%CI%为29.8%-54.4%)、36.0%(23.7%-48.2%)和15.8%(2.6%-28.9%)。

由此可见,城市化、生活在高海拔地区和身患高血压与每日吸烟率低人群的肺功能衰退加速有关。

原始出处:


Catherine H Miele, et al. Environmental exposures and systemic hypertension are risk factors for decline in lung function.Thorax. 2018. http://dx.doi.org/10.1136/thoraxjnl-2017-210477

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    2018-10-10 大爰

    学习并分享!!

    0

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    2018-09-04 大爰

    学习并分享!!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2083237, encodeId=28b4208323ec2, content=<a href='/topic/show?id=fbdb6844879' target=_blank style='color:#2F92EE;'>#环境暴露#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68448, encryptionId=fbdb6844879, topicName=环境暴露)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5V6pBDhhleaA9ZQaNgImyx09qqFom6WIvSGdUoWfKiaWCiaeUfnXMRECAMPA81Wkd4EOicrPibOTudQ/132, createdBy=b9382500209, createdName=ms6127405442416114, createdTime=Fri Aug 10 06:22:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941686, encodeId=273f194168619, content=<a href='/topic/show?id=57eb8203240' target=_blank style='color:#2F92EE;'>#肺功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82032, encryptionId=57eb8203240, topicName=肺功能下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sun Sep 02 14:22:00 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348731, encodeId=8607348e31b3, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Oct 10 08:40:11 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342646, encodeId=0701342646c0, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue Sep 04 15:29:33 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340341, encodeId=6b76340341b9, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Aug 23 09:09:42 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336501, encodeId=a5ba33650155, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:10:07 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336213, encodeId=c48933621394, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Aug 04 08:19:24 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-23 大爰

    学习并分享!!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2083237, encodeId=28b4208323ec2, content=<a href='/topic/show?id=fbdb6844879' target=_blank style='color:#2F92EE;'>#环境暴露#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68448, encryptionId=fbdb6844879, topicName=环境暴露)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5V6pBDhhleaA9ZQaNgImyx09qqFom6WIvSGdUoWfKiaWCiaeUfnXMRECAMPA81Wkd4EOicrPibOTudQ/132, createdBy=b9382500209, createdName=ms6127405442416114, createdTime=Fri Aug 10 06:22:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941686, encodeId=273f194168619, content=<a href='/topic/show?id=57eb8203240' target=_blank style='color:#2F92EE;'>#肺功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82032, encryptionId=57eb8203240, topicName=肺功能下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sun Sep 02 14:22:00 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348731, encodeId=8607348e31b3, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Oct 10 08:40:11 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342646, encodeId=0701342646c0, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue Sep 04 15:29:33 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340341, encodeId=6b76340341b9, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Aug 23 09:09:42 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336501, encodeId=a5ba33650155, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:10:07 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336213, encodeId=c48933621394, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Aug 04 08:19:24 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-05 张新亮1853311252142e2fm

    好文章学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2083237, encodeId=28b4208323ec2, content=<a href='/topic/show?id=fbdb6844879' target=_blank style='color:#2F92EE;'>#环境暴露#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68448, encryptionId=fbdb6844879, topicName=环境暴露)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5V6pBDhhleaA9ZQaNgImyx09qqFom6WIvSGdUoWfKiaWCiaeUfnXMRECAMPA81Wkd4EOicrPibOTudQ/132, createdBy=b9382500209, createdName=ms6127405442416114, createdTime=Fri Aug 10 06:22:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941686, encodeId=273f194168619, content=<a href='/topic/show?id=57eb8203240' target=_blank style='color:#2F92EE;'>#肺功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82032, encryptionId=57eb8203240, topicName=肺功能下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sun Sep 02 14:22:00 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348731, encodeId=8607348e31b3, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Oct 10 08:40:11 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342646, encodeId=0701342646c0, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue Sep 04 15:29:33 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340341, encodeId=6b76340341b9, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Aug 23 09:09:42 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336501, encodeId=a5ba33650155, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:10:07 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336213, encodeId=c48933621394, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Aug 04 08:19:24 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-04 大爰

    学习了谢谢分享!!

    0