Public Health:重度饮酒是导致痴呆症重要的危险因素:柳叶刀子刊

2018-02-27 Chen 生物探索

春节长假期间,探索君曾推送过一篇有关“低剂量酒精对大脑有益”的报道。不过,最新发表在《柳叶刀》子刊上的一项大型研究则需要大家高度警惕了。因为该研究表明,重度饮酒和酒精使用障碍,是导致痴呆症最重要的危险因素。

春节长假期间,探索君曾推送过一篇有关“低剂量酒精对大脑有益”的报道。不过,最新发表在《柳叶刀》子刊上的一项大型研究则需要大家高度警惕了。因为该研究表明,重度饮酒和酒精使用障碍,是导致痴呆症最重要的危险因素。

2月20日,发表在The Lancet Public Health杂志上,题为“Contribution of alcohol use disorders to the burden of dementia in France 2008–13: a nationwide retrospective cohort study”的这篇论文中,科学家们进行了一项全国性的观察研究,以调查酒精使用障碍(Alcohol use disorders)的影响。

研究包括了被诊断患有精神和行为障碍或慢性疾病的人,其疾病都是由酒精的慢性有害使用引起的。分析结果显示,57000例早发性痴呆(65岁之前)中,大多数(57%)与慢性重度饮酒有关。此外,早发性痴呆有明显的性别差异。虽然大多数痴呆患者是女性,但几乎三分之二(64.9%)的早发性痴呆患者是男性。

参与该研究的Jürgen Rehm博士说:“我们的研究结果表明,重度饮酒和酒精使用障碍是导致痴呆症最重要的危险因素,其中,对65岁前就开始的痴呆尤为重要。酒精使用障碍也与导致痴呆发病的所有其他独立危险因素有关,如吸烟、高血压糖尿病、抑郁和听力损失等。”

Rehm博士还指出,平均而言,酒精使用障碍会使预期寿命(life expectancy)缩短超过20年,而痴呆症是导致这些人死亡的主要原因之一。不过,值得庆幸的是,酒精诱导的大脑损伤和痴呆是可以预防的。

作者们表示,世界卫生组织对慢性重度饮酒的定义为男性平均每天饮用超过60克纯酒精,女性平均每天饮用超过40克纯酒精。鉴于这项研究中发现的强相关性,他们建议,对重度饮酒实施筛查和干预;对酒精使用障碍进行治疗,以减少因酒精引起的痴呆症负担。

论文的共同作者Bruce Pollock博士强调:“作为一名老年精神病医生,我经常能看到酒精使用障碍对痴呆症的影响,不幸的是,在这些病例中,酒精治疗干预可能太晚,因此无法改善认知能力。我认为,对问题饮酒(problem drinking)的筛查、干预,以及对酒精使用障碍的治疗需要开始得更早。”

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    2019-01-16 shizhenshan
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    2018-12-16 Boyinsh
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    2018-02-28 虈亣靌

    学习了.谢谢分享

    0

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    2018-02-28 yfjms

    学习

    0

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