Hypertension:体力活动与高血压发生存在量效关系吗?

2017-03-28 xing.T MedSci原创

这项荟萃分析表明,高血压预防的额外好处发生是由于PA量的增加。

尽管体力活动(PA)和高血压发生之间存在负相关关系,PA和高血压之间定量的剂量-反应关系的全面评估还没有被报道。近日,血管权威杂志Hypertension上发表了一篇荟萃分析文章。研究人员针对包括剂量-反应分析在内的定量评估PA和高血压之间的相关性进行一项荟萃分析。

研究人员检索了PubMed和EMBASE数据库中在2016年11月1日前发表的文献。随机效应广义最小二乘回归模型被用来评估所有研究中PA和高血压风险之间的相关性。限制三次样条曲线被用来模拟剂量-反应关系。

研究人员确定了22篇旨在调查高血压风险和闲暇时间PA或PA之间相关性的文献(29项研究),其中包含了330222名参与者和67698例高血压患者。研究人员发现高血压的风险降低了6%(相对风险为0.94;95%可信区间为0.92-0.96)随着闲暇时间PA每增加10个代谢当量,研究人员发现没有任何证据表明PA和高血压之间存在非线性剂量反应关系(闲暇时间PA的非劣效性P=0.094,总PA的非劣效性P=0.771)。在线性三次样条模型中,当与非活动的个人相比,对于那些符合指南建议最低水平的中度PA(10代谢当量)的参与者发生高血压的风险降低了6%(相对风险为0.94;95%可信区间为0.92-0.97)。

这项荟萃分析表明,高血压预防的额外好处发生是由于PA量的增加。

原始出处:

Xuejiao Liu, et al. Dose–Response Association Between Physical Activity and Incident Hypertension A Systematic Review and Meta-Analysis of Cohort Studies.Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.08994

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    2017-09-18 feather89
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    2017-03-28 半夏微凉

    学习了解一下

    0

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    2017-03-28 milkshark

    值得进一步研究

    0

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