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Biomed Mater：新型低温系统对羟基磷灰石-氧化锆生长及成骨矿化的影响

2019-10-15 不详 网络

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陶瓷和生物陶瓷，如羟基磷灰石和锆，被用于骨组织工程中。羟基磷灰石具有与骨骼相似的化学性质，而锆具有合适的机械性质。本文旨在评估通过基于不同低温（例如873°K（HZ600），923°K（HZ650）和973°K（HZ700））的新系统获得的羟基磷灰石-锆的细胞生长和成骨细胞矿化的能力。通过热重特征和X射线衍射图检查了通过该新系统获得的羟基磷灰石-氧化锆。此外，分析其表面成骨细胞生长和矿化的能力。通

陶瓷和生物陶瓷，如羟基磷灰石和锆，被用于骨组织工程中。羟基磷灰石具有与骨骼相似的化学性质，而锆具有合适的机械性质。本文旨在评估通过基于不同低温（例如873°K（HZ600），923°K（HZ650）和973°K（HZ700））的新系统获得的羟基磷灰石-锆的细胞生长和成骨细胞矿化的能力。

通过热重特征和X射线衍射图检查了通过该新系统获得的羟基磷灰石-氧化锆。此外，分析其表面成骨细胞生长和矿化的能力。通过X射线衍射分析，我们清楚地表明不需要高温处理。另外，可以在650℃下形成四方锆。增殖试验表明，成骨细胞的生长不受任何评估的复合材料的影响。关于成骨标记物Col1，与HZ600和HZ700相比，HZ650的表达增加了2倍。有趣的是，在HZ650上生长的成骨细胞显示出球状分泌物，覆盖着胶原蛋白束和富含钙的细胞外基质，而HZ600和HZ700没有显示出磷酸盐或钙沉积物。

总之，这项研究表明，在650°C下可能生成稳定的四方锆，并且所得的HZ650复合材料能够促进合适的成骨细胞矿化过程。

原始出处：

Bermudez-Reyes B, Lara-Banda M, et al., Effect on growth and osteoblast mineralization of hydroxyapatite-zirconia (HA-ZrO2) obtained by a new low temperature system. Biomed Mater. 2017 Dec 22. doi: 10.1088/1748-605X/aaa3a4.

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    2019-12-04 yahu

    #矿化#

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    2020-09-13 sunylz

    #Bio#

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    2019-10-17 zhaojie88

    #成骨#

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    2019-10-17 medsci248

    #氧化锆#

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    2019-10-17 ms3994565386320060

    #Med#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1721333, encodeId=551e1e21333b6, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Dec 04 15:34:00 CST 2019, time=2019-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918881, encodeId=63351918881b7, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Sep 13 23:34:00 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352220, encodeId=fc41135222091, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Oct 17 12:34:00 CST 2019, time=2019-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459771, encodeId=a7631459e7150, content=<a href='/topic/show?id=00da63996ea' target=_blank style='color:#2F92EE;'>#氧化锆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63996, encryptionId=00da63996ea, topicName=氧化锆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=facd6195692, createdName=medsci248, createdTime=Thu Oct 17 12:34:00 CST 2019, time=2019-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610033, encodeId=70e216100336a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Oct 17 12:34:00 CST 2019, time=2019-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622172, encodeId=9caf16221e286, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Oct 17 12:34:00 CST 2019, time=2019-10-17, status=1, ipAttribution=)]
    2019-10-17 爆笑小医

    #羟基磷灰石#

    0