Cell Rep:研究表明抗抑郁药可能加重耳鸣

2017-09-14 zhuliee 来宝网

【血清素能够加重抑郁患者耳鸣】我们也许都经历过耳鸣,耳鸣会使人感到烦躁和焦虑。来自OHSU的科学家的研究表明,常见的抗抑郁药物可能会使耳鸣情况恶化。



【血清素能够加重抑郁患者耳鸣】我们也许都经历过耳鸣,耳鸣会使人感到烦躁和焦虑。来自OHSU的科学家的研究表明,常见的抗抑郁药物可能会使耳鸣情况恶化。

该研究发表在Cell Reports杂志上,主要关注的是血清素的作用,血清素是大脑中的一种重要的神经调质。研究人员检测了小鼠的耳蜗背核等脑组织,耳蜗背核是控制感觉综合和耳鸣发生的部位。研究人员发现,大脑中这一部分被称为梭形细胞的神经元暴露于血清素时对刺激过度兴奋。

该研究的作者,Laurence Trussell博士说:“我们看到这些神经元的活动经过顶部。”

如果对该发现进一步研究,则需要研究名为选择性血清素再吸收抑制剂(SSRI)抗抑郁药物的作用。SSRIs类药物可以通过增加大脑中的血清素水平从而缓解中度到重度的抑郁和焦虑。血清素是一种化合物,它作为一种神经递质负责维持情绪平衡。

然而,研究表明,SSRIs类药物用于治疗焦虑或抑郁可能会加重患者的耳鸣。

耳鸣是指在没有内部或外部声源时,耳朵对声音的异常感知。

如果你是一个医生,在治疗合并有耳聋或耳鸣的抑郁症患者时,你可能要谨慎的开处方药物缓解焦虑。SSRI可以加强你想解决的事情。

郑泉堂博士指出,现有许多科学文献的回顾表明,许多患者在服用了SSRIs后,耳鸣的发生率增加了。虽然各个文献的结果不尽相同,但是至少有10%的患有耳鸣。

OHSU的科学家随后着重于探索血清素是否能激活神经元细胞膜上的离子通道。如果科学家能够确定一种方法来使这些通道失活,那么他们可能会允许抗抑郁药在耳鸣患者中进行使用。

原始出处:Tang ZQ, Trussell LO. Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific. Cell Rep. 2017 Aug 22;20(8):1844-1854.

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    2017-09-30 维他命
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    2018-02-22 wetgdt
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    2017-09-16 baihao215

    这个只是临床观察+动物实验.值得关注

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Sep 14 20:03:50 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-15 刘煜

    谢谢分享学习了

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Sep 14 20:03:50 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-15 想做点大事的毛护士

    通俗易懂.棒棒哒

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Sep 14 20:03:50 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-14 130****4638

    学习了受益匪浅

    0

  10. 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    2017-09-14 changjiu

    学习了.谢谢

    0

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大脑中的一些活动模式可能是危险的,会产生持续的消极情绪,从而耗尽人们的动机、快乐和希望。在过去的三十年里,像Prozac或Zoloft(统称选择性血清素再吸收抑制剂,简称ssrisa)这样的药物为数百万美国人提供了一种方法来摆脱抑郁,获得更健康的精神状态。

Int J Cancer:抗抑郁药或能降低卵巢上皮癌的风险

卵巢上皮癌是常见的妇科恶性肿瘤,占卵巢肿瘤的;50%-70%.由于EOC早期(I、II期)缺乏典型临床表观。76%的病人在发现时已有腹腔内种植,肝实质和/或胸腔、颅内转移(III、IV期)这是导致较高病死率的主要原因。 抗抑郁药治疗在女性中被广泛使用,主要治疗抑郁症和焦虑症,但目前很少有研究探讨抗抑郁药对妇科癌症风险的影响。

[重复]JAMA:妊娠初期母亲使用抗抑郁药对子代有何影响?

有研究显示,出生前暴露于抗抑郁药与不良结局相关。然而,既往研究可能对混杂的解释不足。2017年4月,发表在《JAMA》的一项回顾性队列研究调查了妊娠初期母亲使用抗抑郁药与子代早产、小于胎龄儿、自闭症谱系障碍和注意力缺陷/多动障碍的相关性。