J Gastroenterology H:肠道菌群与宿主中央肥胖之间的关系

2020-01-22 不详 MedSci原创

人类肠道微生物群组成与代谢异常有关,例如肥胖,糖尿病和胰岛素抵抗。本项研究的目的是检查种族,中央型肥胖和饮食成分对人类肠道微生物组的影响。

背景与目标
人类肠道微生物群组成与代谢异常有关,例如肥胖,糖尿病和胰岛素抵抗。本项研究的目的是检查种族,中央型肥胖和饮食成分对人类肠道微生物组的影响。

方法
本项研究纳入中国(n = 14),马来西亚(n = 10)和印度(n = 11)受试者,其年龄中位数为39岁(范围:22-70岁),粪便样本用于肠道微生物组分析,方法是使用16S rRNA测序,并完成饮食调查表。并分析血清样品中的一组生物标志物(白介素-6,肿瘤坏死因子α,脂联素,裂解的细胞角蛋白18,脂多糖结合蛋白和,变形细胞)。中央型肥胖是由亚洲人的腰围临界值定义的。

结果
炎症细胞因子水平与肥胖之间没有关联。Anaerofilum(P = 0.02),Gemellaceae(P = 0.02),链球菌科(P = 0.03),和Rikenellaceae(P = 0.04)的相对丰度在肥胖组显着降低。

结论
研究表明,肥胖个体的肠道微生物组存在差异。中枢性肥胖人群中某些细菌类群的含量较低。纤维和脂肪/饱和脂肪饮食不是中枢肥胖的关键决定因素。

原始出处:

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    2020-04-17 许安
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    2020-01-24 wincls
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