Ann Otol Rhinol Laryn:氟替卡松安特酰胺鼻腔喷雾对具有鼻息肉和常年性变应性鼻炎病人的嗜酸性粒细胞炎症参数的影响

2017-06-19 AlexYang MedSci原创

正常T细胞表达激活和分泌的调控(RANTES)和嗜酸性粒细胞趋化因子-2被假设为与鼻粘膜慢性炎症中嗜伊红血球过多有关。最近,有研究人员评估了在具有常年性变应性鼻炎患者和非过敏性/过敏性慢性鼻窦炎鼻息肉(CRSwNP)患者,在鼻腔皮质类固醇治疗之前和之后,RANTES和嗜酸性粒细胞趋化因子-2的粘膜产生情况。研究包括了20名PAR患者,20名非过敏性和20名过敏性CRSwNP患者,以及20名健康对照

正常T细胞表达激活和分泌的调控(RANTES)和嗜酸性粒细胞趋化因子-2被假设为与鼻粘膜慢性炎症中嗜伊红血球过多有关。最近,有研究人员评估了在具有常年性变应性鼻炎患者和非过敏性/过敏性慢性鼻窦炎鼻息肉(CRSwNP)患者,在鼻腔皮质类固醇治疗之前和之后,RANTES和嗜酸性粒细胞趋化因子-2的粘膜产生情况。

研究包括了20名PAR患者,20名非过敏性和20名过敏性CRSwNP患者,以及20名健康对照。研究人员在粘膜分泌样品种测量了RANTES和嗜酸性粒细胞趋化因子-2的水平。并且,患有慢性炎症的患者用氟替卡松安特酰胺鼻腔喷雾治疗两周。细胞足额检查和RANTES和嗜酸性粒细胞趋化因子-2在鼻分泌液中的测量分别在治疗前后分别进行。

研究结果表明,RANTES在患有PAR(P<0.05)和非过敏性(P<0.01)和过敏性CRSwNP病人(P<0.001)中的水平鼻对照具有更高的水平。嗜酸性粒细胞趋化因子-2的水平在三个炎症组中的水平鼻对照组更高(P<0.001)。在治疗之后,研究人员发现,RANTES和嗜酸性粒细胞趋化因子-2的浓度水平在3组病人中具有显著的降低。最后,研究人员指出,RANTES和嗜酸性粒细胞趋化因子-2在鼻分泌液中的水平可以作为评估皮质类固醇介入治疗结果的可以信赖的标记。

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    2017-06-27 方舒

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    0

  4. 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  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213201, encodeId=2f692132013c, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jun 20 19:31:08 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213030, encodeId=67ac21303062, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jun 20 08:20:42 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212971, encodeId=d66f2129e10d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Jun 20 06:28:30 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213201, encodeId=2f692132013c, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jun 20 19:31:08 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213030, encodeId=67ac21303062, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jun 20 08:20:42 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212971, encodeId=d66f2129e10d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Jun 20 06:28:30 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-21 mnda
  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=1994951, encodeId=98971994951b1, content=<a href='/topic/show?id=eb8f10351e38' target=_blank style='color:#2F92EE;'>#鼻腔喷雾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103517, encryptionId=eb8f10351e38, topicName=鼻腔喷雾)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a19115, createdName=stfoxst, createdTime=Fri Nov 10 04:43:00 CST 2017, time=2017-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046582, encodeId=27bb20465820f, content=<a href='/topic/show?id=4499e795592' target=_blank style='color:#2F92EE;'>#细胞炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77955, encryptionId=4499e795592, topicName=细胞炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213201, encodeId=2f692132013c, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jun 20 19:31:08 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213030, encodeId=67ac21303062, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jun 20 08:20:42 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212971, encodeId=d66f2129e10d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Jun 20 06:28:30 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-20 thlabcde

    好东西学习了!

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213201, encodeId=2f692132013c, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jun 20 19:31:08 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213030, encodeId=67ac21303062, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jun 20 08:20:42 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212971, encodeId=d66f2129e10d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Jun 20 06:28:30 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-20 明月清辉

    谢谢分享,学习了

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213201, encodeId=2f692132013c, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jun 20 19:31:08 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213030, encodeId=67ac21303062, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jun 20 08:20:42 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212971, encodeId=d66f2129e10d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Jun 20 06:28:30 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-20 刘煜

    学习了谢谢分享。

    0

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