Nanomedicine:3D打印双相仿生结构支架可用于骨软骨再生

2019-04-23 不详 网络

由创伤和/或病理性疾病引起的骨软骨缺损是关键的临床问题。由于供体来源不足和植入组织的潜在免疫排斥,目前的方法仍然不能令人满意 3D打印技术已经显示出制造可定制的仿生组织基质的巨大希望。本研究的旨在研究具有仿生,双相结构的3D打印支架,用于骨软骨再生。为此,研究人员合成纳米羟基磷灰石和转化生长因子β1纳米颗粒并分别分布到双相支架的下层和上层,其使用3D立体平版印刷机制造。结果表明,该支架设计成功地促

由创伤和/或病理性疾病引起的骨软骨缺损是关键的临床问题。由于供体来源不足和植入组织的潜在免疫排斥,目前的方法仍然不能令人满意 3D打印技术已经显示出制造可定制的仿生组织基质的巨大希望。本研究的旨在研究具有仿生,双相结构的3D打印支架,用于骨软骨再生。

为此,研究人员合成纳米羟基磷灰石和转化生长因子β1纳米颗粒并分别分布到双相支架的下层和上层,其使用3D立体平版印刷机制造。结果表明,该支架设计成功地促进了人骨髓间充质干细胞的成骨和软骨分化,以及与成骨和软骨形成相关的增强的基因表达。

总之,该发现表明,具有仿生、双相结构的3D打印骨软骨支架是骨软骨修复和再生的优良候选者。

原始出处:

Zhou X, Esworthy T, et al., 3D printed scaffolds with hierarchical biomimetic structure for osteochondral regeneration. Nanomedicine. 2019 Apr 17. pii: S1549-9634(19)30082-6. doi: 10.1016/j.nano.2019.04.002.

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    2020-01-17 kalseyzl
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    2019-11-22 jeanqiuqiu
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    2019-04-25 lsj630
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